Hypermutation and microsatellite instability in gastrointestinal cancers.
Hypermutation and microsatellite instability in gastrointestinal cancers.
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DOI：
10.18632/oncotarget.22783
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发表时间：
2017-12-19
期刊：
影响因子：
--
通讯作者：
Wakai T
中科院分区：
文献类型：
--
作者：
Yuza K;Nagahashi M;Watanabe S;Takabe K;Wakai T
Recent progress in cancer genome analysis using next-generation sequencing has revealed a high mutation burden in some tumors. The particularly high rate of somatic mutation in these tumors correlates with the generation of neo-antigens capable of eliciting an immune response. Identification of hypermutated tumors is therefore clinically valuable for selecting patients suitable for immunotherapy treatment. There are several known causes of hypermutation in tumors, such as ultraviolet light in melanoma, tobacco smoke in lung cancer, and excessive APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) activity in breast and gastric cancer. In gastrointestinal cancers, one of the leading causes of hypermutation is a defect in DNA mismatch repair, which results in microsatellite instability (MSI). This review will focus on the frequency, characteristics and genomic signature of hypermutated gastrointestinal cancers with MSI. Detection of tumor hypermutation in cancer is expected to not only predict the clinical benefit of immune checkpoint inhibitor treatment, but also to provide better surgical strategies for the patients with hypermutated tumors. Thus, in an era of precision medicine, identification of hypermutation and MSI will play an important role directing surgical and chemotherapeutic treatment.
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影响因子：
3.3
作者：
Falchetti, Mario;Saieva, Calogero;Ottini, Laura
通讯作者：
Ottini, Laura
影响因子：
3.8
作者：
Beghelli, S;de Manzoni, G;Moore, PS
通讯作者：
Moore, PS
影响因子：
5.6
作者：
Copija A;Waniczek D;Witkoś A;Walkiewicz K;Nowakowska-Zajdel E
通讯作者：
Nowakowska-Zajdel E
影响因子：
2.6
作者：
Fang, Wen-Liang;Chang, Shih-Ching;Chiou, Shih-Hwa
通讯作者：
Chiou, Shih-Hwa
DOI：
10.1056/nejmoa1504627
发表时间：
2015-07-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer J;Reckamp KL;Baas P;Crinò L;Eberhardt WE;Poddubskaya E;Antonia S;Pluzanski A;Vokes EE;Holgado E;Waterhouse D;Ready N;Gainor J;Arén Frontera O;Havel L;Steins M;Garassino MC;Aerts JG;Domine M;Paz-Ares L;Reck M;Baudelet C;Harbison CT;Lestini B;Spigel DR
通讯作者：
Spigel DR