The traumatic bone: trauma-induced heterotopic ossification.
The traumatic bone: trauma-induced heterotopic ossification.
复制标题
DOI：
10.1016/j.trsl.2017.06.004
复制
发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Davis TA
中科院分区：
文献类型：
--
作者：
Dey D;Wheatley BM;Cholok D;Agarwal S;Yu PB;Levi B;Davis TA
Heterotopic ossification (HO) is a common occurrence after multiple forms of extensive trauma. These include arthroplasties, traumatic brain and spinal cord injuries, extensive burns in the civilian setting, and combat-related extremity injuries in the battlefield. Irrespective of the form of trauma, heterotopic bone is typically endochondral in structure and is laid down via a cartilaginous matrix. Once formed, the heterotopic bone typically needs to be excised surgically, which may result in wound healing complications, in addition to a risk of recurrence. Refinements of existing diagnostic modalities, like micro- and nano-CT are being adapted toward early intervention. Trauma-induced HO is a consequence of aberrant wound healing, systemic and local immune system activation, infections, extensive vascularization, and innervation. This intricate molecular crosstalk culminates in activation of stem cells that initiate heterotopic endochondral ossification. Development of animal models recapitulating the unique traumatic injuries has greatly facilitated the mechanistic understanding of trauma-induced HO. These same models also serve as powerful tools to test the efficacy of small molecules which specifically target the molecular pathways underlying ectopic ossification. This review summarizes the recent advances in the molecular understanding, diagnostic and treatment modalities in the field of trauma-induced HO.
登录
查看更多内容
影响因子：
4.3
作者：
Cappato S;Tonachini L;Giacopelli F;Tirone M;Galietta LJ;Sormani M;Giovenzana A;Spinelli AE;Canciani B;Brunelli S;Ravazzolo R;Bocciardi R
通讯作者：
Bocciardi R
影响因子：
3.7
作者：
Brownley RC;Agarwal S;Loder S;Eboda O;Li J;Peterson J;Hwang C;Breuler C;Kaartinen V;Zhou B;Mishina Y;Levi B
通讯作者：
Levi B
影响因子：
4.6
作者：
Agarwal S;Loder S;Cholok D;Peterson J;Li J;Fireman D;Breuler C;Hsieh HS;Ranganathan K;Hwang C;Drake J;Li S;Chan CK;Longaker MT;Levi B
通讯作者：
Levi B
影响因子：
3.4
作者：
Ahlers ST;Vasserman-Stokes E;Shaughness MC;Hall AA;Shear DA;Chavko M;McCarron RM;Stone JR
通讯作者：
Stone JR
DOI：
10.1002/jbmr.2820
发表时间：
2016-09
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Chakkalakal SA;Uchibe K;Convente MR;Zhang D;Economides AN;Kaplan FS;Pacifici M;Iwamoto M;Shore EM
通讯作者：
Shore EM