DETECTION OF ABNORMAL MEMORY DECLINE IN MILD CASES OF ALZHEIMERS-DISEASE USING CERAD NEUROPSYCHOLOGICAL MEASURES
DETECTION OF ABNORMAL MEMORY DECLINE IN MILD CASES OF ALZHEIMERS-DISEASE USING CERAD NEUROPSYCHOLOGICAL MEASURES
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DOI：
10.1001/archneur.1991.00530150046016
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发表时间：
1991-03-01
影响因子：
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通讯作者：
HEYMAN, A
中科院分区：
文献类型：
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作者：
WELSH, K;BUTTERS, N;HEYMAN, A
本研究旨在确定 CERAD（建立阿尔茨海默病登记协会）神经心理学电池组中包含的哪些记忆任务能够最好地区分早期阿尔茨海默病患者与认知正常的老年对照受试者，并且最好地区分痴呆过程的不同严重程度。 CERAD 阿尔茨海默病患者样本按照疾病严重程度分为轻度、中度或重度痴呆患者，并与对照组的性别、年龄和教育程度进行匹配。 使用多变量程序和切割分数，确定了每种记忆测量在区分这些组和对照组受试者方面的功效。 延迟回忆测试被认为是最好的整体歧视措施。 其他记忆测试，即立即回忆、侵入错误和识别记忆，总体辨别能力较差。 没有发现 CERAD 记忆测量对于评估痴呆症的严重程度特别有效。 这些发现表明，延迟回忆测试可能对阿尔茨海默病的早期检测特别有用，并且在社区调查中筛查痴呆症时应考虑使用。
The present study was designed to determine which of the memory tasks included in the CERAD (Consortium to Establish a Registry for Alzheimer's Disease) neuropsychological battery best differentiate patients with early Alzheimer's disease from cognitively normal elderly control subjects and also best distinguish between the various levels of severity of the dementia process. A sample of CERAD patients with Alzheimer's disease was stratified by disease severity into those with mild, moderate, or severe dementia and matched with control subjects for sex, age, and education. Using multivariate procedures and cutting scores, the efficacy of each memory measure in distinguishing between these groups and control subjects was determined. The test for delayed recall was found to be the best overall discriminatory measure. The other tests of memory, ie, immediate recall, intrusion errors, and recognition memory, had poor overall discriminability. None of the CERAD memory measures were found to be particularly powerful in staging the severity of dementia. These findings suggest that tests for delayed recall may be particularly useful in the early detection of Alzheimer's disease and should be considered in screening batteries for dementia in community surveys.