MECHANISM OF ENHANCED TRANS-CELLULAR POTASSIUM SECRETION IN MAN WITH CHRONIC-RENAL-FAILURE
MECHANISM OF ENHANCED TRANS-CELLULAR POTASSIUM SECRETION IN MAN WITH CHRONIC-RENAL-FAILURE
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DOI：
10.1038/ki.1987.152
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发表时间：
1987-06-01
影响因子：
19.6
通讯作者：
HAYSLETT, JP
中科院分区：
文献类型：
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作者：
PANESE, S;MARTIN, RS;HAYSLETT, JP
我们实验室以前的研究表明，慢性肾功能衰竭患者直肠的净钾分泌是对照组的2.5倍。本研究的目的是确定是否K分泌在人体大肠中涉及一个积极的过程，以及是否一个积极的运输过程帐户，至少部分，为净K分泌的肾功能不全患者的上升。在净水和电解质转运接近零的条件下进行研究，并将观察到的跨直肠粘膜的K和Na分布与预期的平衡值进行比较。在对照受试者中，27.6 .+-的主动转运。2.6对于K和63 ±，观察到mV。4.2 mV为Na。在慢性肾衰竭患者中证实了类似的值。这些研究的结果表明，净分泌钾和吸收钠，至少在部分，由主动运输过程，并表明，由于主动钾分泌不受损害，净钾分泌的上升，在肾功能不全患者是由主动分泌以及被动驱动力。
Previous studies from our laboratory demonstrated that net K secretion in human rectum was 2.5-fold higher in patients with chronic renal failure than in controls. The present study was performed to determine whether K secretion in human large intestine involves an active process and whether an active transport process accounts, at least in part, for the rise in net K secretion in patients with renal insufficiency. Studies were performed under conditions when net water and electrolyte transport approached zero, and the observed distribution of K and Na across the rectal mucosa was compared to expected equilibrium values. In control subjects an active transport of 27.6 .+-. 2.6 mV was observed for K and 63 .+-. 4.2 mV for Na. Similar values were demonstrated in patients with chronic renal failure. The results of these studies demonstrated that net secretion of K and absorption of Na are governed, at least in part, by active transport processes, and suggest that, since active K secretion is not impaired, the rise in net K secretion in patients with renal insufficiency is caused by active secretion as well as by passive driving forces.