Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies
Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies
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DOI：
10.1210/jc.2003-030228
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发表时间：
2003-09-01
影响因子：
5.8
通讯作者：
Kilby, MD
中科院分区：
文献类型：
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作者：
Chan, S;Kachilele, S;Kilby, MD
我们描述了整个妊娠期间正常人胎盘中特定碘甲状腺原氨酸脱碘酶 mRNA 的表达（使用定量 RT-PCR）和活性，并将我们的发现与受宫内生长受限 (IUGR) 影响的妊娠胎盘中的结果进行了比较。胎盘中表达的主要脱碘酶为 III 型 (D3)； II型(D2)也存在。一般来说，D2 和 D3 酶（以及编码这些酶的 mRNA）的活性在妊娠早期较高。
We have described the expression of specific iodothyronine deiodinase mRNAs (using quantitative RT-PCR) and activities in normal human placentas throughout gestation and compared our findings to those in placentas from pregnancies affected by intrauterine growth restriction (IUGR). The predominant deiodinase expressed in placenta was type III (D3); type II (D2) was also present. In general terms, the activities of the enzymes D2 and D3 (and mRNAs encoding these enzymes) were higher earlier in gestation (