Identifying Mechanisms of Endometriosis-Associated Reduced Fecundity in a Rat Model: Novel Insights toward Understanding Human Infertility.
Identifying Mechanisms of Endometriosis-Associated Reduced Fecundity in a Rat Model: Novel Insights toward Understanding Human Infertility.
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DOI：
10.1007/978-3-030-51856-1_2
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
K. Sharpe-Timms;H. Nabli;J. Stilley
中科院分区：
文献类型：
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作者：
K. Sharpe-Timms;H. Nabli;J. Stilley
子宫内膜异位症的存在至少从十九世纪就已为人所知，但由于缺乏对不孕原因的了解，因此子宫内膜异位症的治疗方法不足，对生殖医学造成了重大挑战。全世界的妇女不仅承受着痛苦和不孕，还承受着经济、社会和生理负担。由于存在许多令人困惑的个人和环境因素，对女性生殖事件的研究很难进行，而且由于生殖组织和细胞（尤其是胚胎）的工作性质，在伦理上也受到限制。动物模型是研究子宫内膜异位症导致人类生殖异常和不孕的机制的可行辅助手段。本章讨论了导致子宫内膜异位症不孕的生殖异常以及成熟的动物模型，这些模型有助于破译这些问题并导致迄今为止未知的非手术、非激素方法来治疗女性子宫内膜异位症。此外，对子宫内膜异位症对发育的影响的研究首次揭示了大鼠模型中雌性和雄性后代的跨代生育力低下，为了解子宫内膜异位症的家族性质和可能的表观遗传参与提供了见解。
The existence of endometriosis has been known since at least the nineteenth century, yet the lack of understanding of causes of infertility and therefore inadequate treatment approaches in endometriosis creates a significant challenge in reproductive medicine. Women worldwide suffer not only pain and infertility but also economical, societal, and physiological burdens. Studies of reproductive events in women are difficult to conduct due to a host of confounding personal and environmental factors and ethically limited due to the very nature of working with reproductive tissues and cells, especially embryos. Animal models are a viable adjunct to study mechanisms causing human reproductive anomalies and infertility in endometriosis. This chapter discusses reproductive anomalies causing infertility in endometriosis and well-established animal models which help decipher the problems and lead to heretofore unknown nonsurgical, nonhormonal methods to manage endometriosis in women. In addition, studies of effects of developmental exposure to endometriosis are revealing for the first time, in both female and male offspring, transgenerational subfertility in a rat model providing insights into the familial nature of endometriosis and possible epigenetic involvement.