Rationale of Drug Encapsulation and Release from Biocompatible Porous Metal-Organic Frameworks
Rationale of Drug Encapsulation and Release from Biocompatible Porous Metal-Organic Frameworks
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DOI：
10.1021/cm400798p
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发表时间：
2013-07-23
影响因子：
8.6
通讯作者：
Serre, Christian
中科院分区：
文献类型：
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作者：
Cunha, Denise;Ben Yahia, Mouna;Serre, Christian
使用一系列具有不同拓扑、连接性和化学成分的多孔生物相容性金属有机框架 (MOF)，对控制 (i) 活性成分封装（溶剂、起始材料脱水、药物/材料比例、浸泡时间和多次连续浸渍）和 (i) 递送动力学（结构、极性等）的驱动力进行了联合实验和计算系统探索。选择降脂化妆品咖啡因作为活性分子。它的封装对化妆品行业来说是一个挑战，因为它很容易结晶，导致负载不良（
A joint experimental and computational systematic exploration of the driving forces that govern (i) encapsulation of active ingredients (solvent, starting material dehydration, drug/material ratio, immersion time, and several consecutive impregnations) and (i) its kinetics of delivery (structure, polarity, ...) was performed using a series of porous biocompatible metal-organic frameworks (MOFs) that bear different topologies, connectivities, and chemical compositions. The liporeductor cosmetic caffeine was selected as the active molecule. Its encapsulation is a challenge for the cosmetic industry due to its high tendency to crystallize leading to poor loadings (