The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain.
The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain.
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DOI：
10.1016/j.jbc.2021.101085
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Usachev YM
中科院分区：
文献类型：
--
作者：
Warwick CA;Keyes AL;Woodruff TM;Usachev YM
补体级联是先天免疫系统的关键组成部分，通过一系列酶促反应快速招募，以识别和清除病原体并促进组织修复。尽管补体级联在免疫学中的作用已广为人知，但最近的研究强调了补体级联在神经免疫相互作用以及发育、衰老和疾病状态期间神经元过程调节中的新的和意想不到的作用。补体信号传导对于指导神经元对组织损伤、神经创伤和神经病变的反应特别重要。在生理条件下，补体依赖性神经元兴奋性、突触强度和神经突重塑的变化促进神经再生、组织修复和愈合。然而，在多种病理学中，补体级联失调会导致慢性炎症、持续性疼痛和神经功能障碍。这篇综述描述了我们对补体系统和神经元之间发生的多方面交叉通讯的理解的最新进展。我们特别关注补体信号传导调节健康和疾病疼痛处理中伤害感受通路中神经元兴奋性和突触可塑性的分子和细胞机制。最后，我们讨论了这个快速发展领域的未来以及我们认为需要解决的重大知识差距。
The complement cascade is a key component of the innate immune system that is rapidly recruited through a cascade of enzymatic reactions to enable the recognition and clearance of pathogens and promote tissue repair. Despite its well-understood role in immunology, recent studies have highlighted new and unexpected roles of the complement cascade in neuroimmune interaction and in the regulation of neuronal processes during development, aging, and in disease states. Complement signaling is particularly important in directing neuronal responses to tissue injury, neurotrauma, and nerve lesions. Under physiological conditions, complement-dependent changes in neuronal excitability, synaptic strength, and neurite remodeling promote nerve regeneration, tissue repair, and healing. However, in a variety of pathologies, dysregulation of the complement cascade leads to chronic inflammation, persistent pain, and neural dysfunction. This review describes recent advances in our understanding of the multifaceted cross-communication that takes place between the complement system and neurons. In particular, we focus on the molecular and cellular mechanisms through which complement signaling regulates neuronal excitability and synaptic plasticity in the nociceptive pathways involved in pain processing in both health and disease. Finally, we discuss the future of this rapidly growing field and what we believe to be the significant knowledge gaps that need to be addressed.
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DOI：
10.1523/jneurosci.3795-08.2008
发表时间：
2008-12-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Binshtok AM;Wang H;Zimmermann K;Amaya F;Vardeh D;Shi L;Brenner GJ;Ji RR;Bean BP;Woolf CJ;Samad TA
通讯作者：
Samad TA
影响因子：
4.2
作者：
Anderson, AJ;Robert, S;Cotman, CW
通讯作者：
Cotman, CW
影响因子：
8.8
作者：
Clark, J. David;Qiao, Yanli;Yeomans, David C.
通讯作者：
Yeomans, David C.
影响因子：
82.9
作者：
Chen, Chun-Jen;Kono, Hajime;Rock, Kenneth L.
通讯作者：
Rock, Kenneth L.
影响因子：
4.2
作者：
Bellander, BM;Singhrao, SK;Svensson, M
通讯作者：
Svensson, M