Disposition of homovanillic acid in the primate.
Disposition of homovanillic acid in the primate.
复制标题
高香草酸在灵长类动物中的分布。
DOI：
10.1007/bf00999612
复制
发表时间：
1987
影响因子：
3.6
通讯作者：
Asch,RH
中科院分区：
文献类型：
--
作者：
Miller,AL;Keenan,RW;Maas,JW;Asch,RH
先前的研究表明高香草酸是多巴胺在灵长类动物中枢神经系统（CNS）中的主要代谢产物。然而，在对全身给予氘代高香草酸的灵长类动物的研究中，在接下来的4-48小时内，只有50%的给药量在尿液中被回收。这些发现使人们不清楚高香草酸是否有一个缓慢翻转的隔室，高香草酸转化为另一种化合物，或者高香草酸通过非肾脏途径从体内排泄。我们合成了[3 H]高香草酸，并将其静脉注射给四只恒河猴。在随后的4小时内，在尿液中回收了94.9 ± 8.9%（SD）的给药放射性，几乎完全以高香草酸的形式回收。这些结果与以下解释一致：在灵长类动物中，高香草酸没有一个主要的代谢缓慢的身体池，也没有代谢为其他化合物的显著性，也没有非肾脏排泄的证据。
Prior studies have shown that homovanillic acid is the principal metabolite of dopamine in the primate central nervous system (CNS). In studies of primates given deuterated homovanillic acid systemically, however, only 50% of the administered amounts have been recovered in the urine over the next 4–48 hr. These findings have left it unclear whether there is a slowly turning-over compartment of homovanillic acid, conversion of homovanillic acid to another compound, or excretion of homovanillic acid from the body by a nonrenal route. We synthesized [3H]homovanillic acid and administered it intravenously to four rhesus monkeys. Over the subsequent 4 hr, 94.9 ± 8.9% (SD) of the administered radioactivity was recovered in the urine, almost entirely as homovanillic acid. These results are consistent with the interpretation that, in primates, there is not a major body pool of homovanillic acid with slow turnover, nor is metabolism to other compounds significant, nor is there evidence for nonrenal excretion.