Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis.
Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis.
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鼠尾草酚调节实验性自身免疫性脑脊髓炎中 Th17 细胞分化和小胶质细胞开关
DOI：
10.3389/fimmu.2018.01807
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发表时间：
2018
影响因子：
7.3
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Li X;Zhao L;Han JJ;Zhang F;Liu S;Zhu L;Wang ZZ;Zhang GX;Zhang Y
药用植物作为开发新型小分子治疗药物的资源库，已有数千年的历史。鼠尾草酚是一种来源于迷迭香（Rosmarinus officinalis，迷迭香）和鼠尾草（Salvia officinalis）的具有生物活性的二萜类化合物，广泛应用于治疗多种自身免疫性疾病。本研究旨在探讨鼠尾草酚对多发性硬化（MS）动物模型实验性自身免疫性脑脊髓炎（EAE）的治疗作用及其分子机制。鼠尾草酚治疗显著缓解了髓鞘少突胶质细胞糖蛋白（MOG 35 -55）肽诱导的EAE模型的临床发展，显著减少了炎性细胞浸润到中枢神经系统和减少脱髓鞘。鼠尾草酚还能抑制Th 17细胞的分化和信号转导与转录激活因子3的磷酸化，并阻断转录因子NF-κB的核转位。在被动EAE模型中，鼠尾草酚处理也显著防止了Th 17细胞的致病性。此外，鼠尾草酚在EAE的慢性阶段发挥其治疗作用，并显着改变浸润的巨噬细胞/小胶质细胞的表型。综上所述，我们的研究结果表明，鼠尾草酚作为自身免疫性疾病（如MS）的治疗剂具有巨大的开发潜力。
Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases. In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG35–55) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken together, our results show that carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as MS.
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影响因子：
8.2
作者：
Chen, Chien-chung;Chen, Hui-ling;Wung, Being-sun
通讯作者：
Wung, Being-sun
影响因子：
4.6
作者：
Giacomelli C;Daniele S;Natali L;Iofrida C;Flamini G;Braca A;Trincavelli ML;Martini C
通讯作者：
Martini C
影响因子：
9.3
作者：
Foresti, Roberta;Bains, Sandip K.;Motterlini, Roberto
通讯作者：
Motterlini, Roberto
DOI：
10.1073/pnas.0600666103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Chen, Zhi;Laurence, Arian;O'Shea, John J.
通讯作者：
O'Shea, John J.
影响因子：
4.4
作者：
Mathur, Anubhav N.;Chang, Hua-Chen;Kaplan, Mark H.
通讯作者：
Kaplan, Mark H.