EFFECT OF CIGARETTE-SMOKING ON RECURRENCE OF CROHNS-DISEASE
EFFECT OF CIGARETTE-SMOKING ON RECURRENCE OF CROHNS-DISEASE
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DOI：
10.1016/0016-5085(90)90324-t
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发表时间：
1990-05-01
期刊：
影响因子：
29.4
通讯作者：
FICK, G
中科院分区：
文献类型：
--
作者：
SUTHERLAND, LR;RAMCHARAN, S;FICK, G
在 174 名患者的历史队列中评估了吸烟对先前因克罗恩病需要手术的患者复发（在本研究中定义为需要重复手术）的影响。平均随访时间为 10.8 年。 5年和10年复发率分别为28%和56%。吸烟者（36%、70%）和非吸烟者（20%、41%）的五年和十年比率存在显着差异。当患者按性别分层时，女性（比值比 4.2，95% 置信区间 2.0-4.2）的风险增加比男性（比值比 1.5，95% 置信区间 0.8-6.0）更明显。剂量反应关系的证据可以在女性身上找到，但在男性身上却找不到。吸烟不仅可能是克罗恩病发展的危险因素，还可能影响手术后的疾病活动。
The effect of cigarette smoking on recurrence (defined in this study as the need for repeat surgery) in patients who had previously required surgery for Crohn''s disease was assessed in a historical cohort of 174 patients. Mean follow-up was 10.8 yr. The 5- and 10-yr recurrence rates were 28% and 56%, respectively. Five- and 10-yr rates were significantly different for smokers (36%, 70%) and nonsmokers (20%, 41%). When patients were stratified by gender, the increased risk was more apparent in women (odds ratio 4.2, 95% confidence interval 2.0-4.2) than in men (odds ratio 1.5, 95% confidence interval 0.8-6.0). Evidence for a dose-response relationship could be identified in women but not men. Cigarette smoking may not only be a risk factor for development of Crohn''s disease but also may influence disease activity following surgery.