Thyroid-Stimulating Hormone Levels Are Positively Associated with Insulin Resistance
Thyroid-Stimulating Hormone Levels Are Positively Associated with Insulin Resistance
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DOI：
10.12659/msm.905774
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发表时间：
2018-01-17
影响因子：
3.1
通讯作者：
Mao, Xiaoming
中科院分区：
文献类型：
--
作者：
Zhu, Ping;Liu, Xinliang;Mao, Xiaoming
背景：已有报道，显性和轻度甲状腺功能障碍与胰岛素抵抗（IR）有关。我们进行了这项回顾性研究，以评估促甲状腺激素（TSH）水平的参考范围内和IR。材料/方法：共447例门诊患者参加了这项研究：298例2型糖尿病和149例非糖尿病患者。根据HbA 1c临界值7%，将糖尿病患者额外分为2组：高HbA 1c组（n=240）和低HbA 1c组（n=58）。结果：非糖尿病组和糖尿病组TSH水平与HOMA-IR均呈正相关（r=0.210，p=0.011; r=0.451，p <0.01），且两者之间无显著性差异（P> 0.05）。
Background: It has been reported that overt and mild thyroid dysfunctions are associated with insulin resistance (IR). We performed this retrospective study to evaluate the relationships between thyroid-stimulating hormone (TSH) levels within the reference range and IR.Material/Methods: A total of 447 outpatients were enrolled in this study: 298 with type 2 diabetes mellitus and 149 nondiabetic individuals. Based on a cutoff HbA1c value of 7%, diabetic patients were additionally divided into 2 groups: a high-HbA1c group (n=240) and a low-HbA1c group (n=58). The relationships of TSH levels and HOMA-IR were computed using linear regression models.Results: TSH levels were positively and linearly associated with HOMA-IR in both the nondiabetic and diabetic groups (r=0.210, p=0.011 and r=0.451, p