Absorption, distribution, and excretion of ammonium perfluorooctanoate (APFO) after oral administration to various species
Absorption, distribution, and excretion of ammonium perfluorooctanoate (APFO) after oral administration to various species
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DOI：
10.1080/01480540600561361
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Kennedy, GL
中科院分区：
文献类型：
--
作者：
Hundley, SG;Sarrif, AM;Kennedy, GL
用单次口服剂量的全氟辛酸c -14铵（APFO）对雄性和雌性小鼠、大鼠、仓鼠和家兔进行了120 h（家兔168 h）的排泄和组织分布观察。在本研究中，我们观察到由c -14标记的APFO引起的c -14放射性的排泄和处置在性别和物种上的巨大差异。在给药后120 h，雌性大鼠和雄性仓鼠排出的C-14活性超过原来的99%；相反，在给药后120小时，雄性大鼠和雌性仓鼠的C-14活性分别仅为原来的39%和60%。雄性和雌性家兔排泄C-14活性的速度和完全程度与雌性大鼠和雄性仓鼠相同，而雄性和雌性小鼠在给药后120小时排泄的C-14活性仅为原始水平的21%。快速排泄者（雌性大鼠、雄性仓鼠、雄性和雌性兔子）在献祭时的器官和组织中含有可忽略不计的C-14。缓慢排泄者在血液和肝脏中显示出最高的C-14浓度，其次是肾脏、肺和皮肤。
Male and female mice, rats, hamsters, and rabbits were treated with a single oral dose of C-14-ammonium perfluorooctanoate (APFO), and the excretion and tissue distributions were followed for 120 h (168 h in the rabbit). Substantial sex and species differences in the excretion and disposition of C-14-radioactivity derived from C-14-labeled APFO were observed in this study. The female rat and the male hamster excreted more than 99% of the original C-14 activity by 120 h after dosing; conversely, the male rat and the female hamster excreted only 39% and 60% of the original C-14 activity, respectively, by 120 h postdosing. The male and female rabbits excreted the C-14 activity as rapidly and completely as the female rat and the male hamster, whereas male and female mice excreted only 21% of the original C-14 activity by 120 h postdosing. The rapid excretors (female rat, male hamster, and male and female rabbits) contained negligible amounts of C-14 in organs and tissues at sacrifice. The slow excretors exhibited the highest C-14 concentrations in the blood and liver followed by the kidneys, lungs, and skin.