Longitudinal Monitoring of SARS-CoV-2 RNA on High-Touch Surfaces in a Community Setting
Longitudinal Monitoring of SARS-CoV-2 RNA on High-Touch Surfaces in a Community Setting
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DOI：
10.1021/acs.estlett.0c00875
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发表时间：
2021-02-09
影响因子：
10.9
通讯作者：
Pickering, Amy J.
中科院分区：
文献类型：
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作者：
Harvey, Abigail P.;Fuhrmeister, Erica R.;Pickering, Amy J.
表面污染的环境监测是了解社区环境中SARS-CoV-2传播的一种尚未开发的工具。在2020年4月至6月2019冠状病毒病爆发期间，我们在马萨诸塞州一个小镇对高接触无孔表面进行了纵向拭子取样。348个表面样本中有29个（8.3%）检测出SARS-CoV-2 RNA阳性，包括人行横道按钮、垃圾桶把手和重要商业入口（杂货店、酒类商店、银行和加油站）的门把手。通过定量微生物风险评估，接触被污染表面的感染风险估计较低（小于5 / 10000），表明污染物在SARS-CoV-2社区传播中发挥的作用很小。每周阳性样本的百分比（每周n = 33个不同表面）在7天的提前期内最能预测城市级COVID-19病例的变化。对高接触表面的SARS-CoV-2 RNA进行环境监测可能是提供COVID-19病例趋势早期预警的有用工具。
Environmental surveillance of surface contamination is an unexplored tool for understanding transmission of SARS-CoV-2 in community settings. We conducted longitudinal swab sampling of high-touch non-porous surfaces in a Massachusetts town during a COVID-19 outbreak from April to June 2020. Twenty-nine of 348 (8.3%) surface samples were positive for SARS-CoV-2 RNA, including crosswalk buttons, trash can handles, and door handles of essential business entrances (grocery store, liquor store, bank, and gas station). The estimated risk of infection from touching a contaminated surface was low (less than 5 in 10,000) by quantitative microbial risk assessment, suggesting fomites play a minimal role in SARS-CoV-2 community transmission. The weekly percentage of positive samples (out of n = 33 unique surfaces per week) best predicted variation in city-level COVID-19 cases with a 7-day lead time. Environmental surveillance of SARS-CoV-2 RNA on high-touch surfaces may be a useful tool to provide early warning of COVID-19 case trends.