Stable long-term pulmonary function after myeloablative double cord blood transplant.
Stable long-term pulmonary function after myeloablative double cord blood transplant.
复制标题
清髓性双脐带血移植后肺功能长期稳定。
DOI：
10.1016/j.bbmt.2011.08.008
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Delaney,Colleen
中科院分区：
文献类型：
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作者：
Milano,Filippo;Chien,JasonW;Riffkin,Ivy;Gutman,JonathanA;Newell,Laura;Pergam,StevenA;Delaney,Colleen
肺功能障碍已被很好地描述后清髓性移植与传统的异基因供体，但是，是否与脐带血作为干细胞来源的替代供体移植后的风险是相似的尚未调查。我们对清髓性预处理后接受双脐血移植的患者进行了回顾性分析。在移植前和移植后80天、1年和2年进行肺功能检查，最终分析包括56例患者。在移植后1年，未观察到肺功能检查值的平均值和平均变化相对于基线的显著变化。从基线到移植后1年，75%的患者的肺功能下降率<5%; 58%的患者报告了轻度肺功能异常。非感染性肺部并发症的累积发生率为9.7%。需要进一步的前瞻性研究来证实这些发现。
Pulmonary dysfunction has been well described after myeloablative transplantation with conventional allogeneic donors; however, whether the risk is similar after alternative donor transplantation with cord blood as the stem cell source has not yet been investigated. We performed a retrospective analysis of patients who underwent double cord blood transplantation after myeloablative conditioning. Pulmonary function tests were performed pretransplantation and at day 80, 1 year, and 2 years posttransplantation, with 56 patients included in the final analysis. No significant change from baseline with respect to the mean values and mean change in pulmonary function test values were observed at 1 year posttransplantation. The rate of lung function decline from baseline to 1 year posttransplantation was <5% in 75% patients; mildly abnormal lung function was reported in 58% of the patients. The cumulative incidence of noninfectious pulmonary complications was 9.7%. Future prospective studies are needed to confirm these findings.