Efficient Synthesis and Fungicidal Activities of 2-Alkylthiobenzofuro[3,2-d]Pyrimidinones
Efficient Synthesis and Fungicidal Activities of 2-Alkylthiobenzofuro[3,2-d]Pyrimidinones
复制标题
DOI：
10.1080/10426500903008922
复制
发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Yanggen Hu;Wenqiang Wang;M. Ding
中科院分区：
文献类型：
--
作者：
Yanggen Hu;Wenqiang Wang;M. Ding
2-烷硫基苯并呋喃并[3,2-d]嘧啶酮5和6是通过2,3-二氢-2-硫代苯并呋喃[3,2-d]嘧啶-4(1H)-酮4的S-烷基化合成的，其是通过亚氨基正膦2与CS2的氮杂维蒂希反应以及产物与各种胺的进一步反应获得的。化合物5和6表现出杀菌活性。例如，具有小N-取代甲基的化合物6a在50 mg/L时对Dothiorella gregaria表现出最佳的抑制活性（91%）。本文提供了补充材料。请访问出版商的《磷、硫、硅及相关元素》在线版本，查看免费的补充文件。
2-Alkylthiobenzofuro[3,2-d]pyrimidinones 5 and 6 were synthesized by S-alkylation of 2,3-dihydro-2-thioxobenzofuro[3,2-d]pyrimidin-4(1H)-ones 4, which were obtained via aza-Wittig reaction of iminophosphorane 2 with CS2 and further reaction of the product with various amines. Compounds 5 and 6 exhibited fungicidal activity. For example, compound 6a, which has a small N-substituted methyl group, showed the best inhibitive activity (91%) against Dothiorella gregaria at 50 mg/L. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.