Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
复制标题
DOI：
10.1038/s41586-019-1419-5
复制
发表时间：
2019-08-01
期刊：
影响因子：
64.8
通讯作者：
Koh, Gou Young
中科院分区：
文献类型：
--
作者：
Ahn, Ji Hoon;Cho, Hyunsoo;Koh, Gou Young
最近的研究表明，脑膜淋巴管（mLV），主要是在头骨的背侧部分，参与脑脊液（CSF）的清除，但CSF引流的确切途径仍然未知。在这里，我们揭示了mLV在这个过程中，通过可视化其独特的解剖位置和表征其专门的形态学特征，这有利于脑脊液的吸收和引流的颅底部分的重要性。与背侧mLV不同，基底mLV具有位于小鼠蛛网膜下腔附近的淋巴管和毛细血管。我们还表明，基础mLV是CSF大分子清除的热点，mLV的完整性和CSF引流都随着年龄的增长而受损。我们的研究结果应该增加了解mLVs如何有助于与衰老相关的神经病理生理过程。
Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route of CSF drainage is still unknown. Here we reveal the importance of mLVs in the basal part of the skull for this process by visualizing their distinct anatomical location and characterizing their specialized morphological features, which facilitate the uptake and drainage of CSF. Unlike dorsal mLVs, basal mLVs have lymphatic valves and capillaries located adjacent to the subarachnoid space in mice. We also show that basal mLVs are hotspots for the clearance of CSF macromolecules and that both mLV integrity and CSF drainage are impaired with ageing. Our findings should increase the understanding of how mLVs contribute to the neuropathophysiological processes that are associated with ageing.