EFFECT OF LIGATING A UTERINE ARTERY ON FETAL AND PLACENTAL DEVELOPMENT IN RAT
EFFECT OF LIGATING A UTERINE ARTERY ON FETAL AND PLACENTAL DEVELOPMENT IN RAT
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DOI：
10.1095/biolreprod14.3.246
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发表时间：
1976-01-01
影响因子：
3.6
通讯作者：
BRUCE, NW
中科院分区：
文献类型：
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作者：
BRUCE, NW
100只大鼠分别于妊娠第4、5、6、7、8、9、10、12天结扎左、右子宫动脉。子宫动脉结扎对第22天胎儿的存活率、畸形率和性别比均无明显影响。胎儿体重轻微下降，胎盘重量增加，特别是结扎后第9天。胎盘肥大是对子宫循环受损的一种适应，哺乳动物胎儿的营养、呼吸和排泄几乎完全依赖胎盘。它的生长速度被认为是由胎盘的功能能力改变的，然而，胎儿的需求可能反过来影响胎盘的生长和功能的可能性很少得到考虑。然而，在慢性贫血妇女（Beischer等人，1968）和大鼠急性失血后，胎盘肥大已被观察到（Bruce和Cabral， 1975）；在这种情况下，可能需要增加的功能能力来补偿血02含量或动脉灌注压的降低。
The left or right uterine artery was ligated in 100 rats on Day 4, 5, 6, 7, 8, 9, 10 or 12 of gestation. Uterine arterial ligation had no apparent effect on survival, malformation or sex ratios of fetuses examined on Day 22. There was a small decrease in fetal weight and an increase in placental weight particularly after ligation on Day 9. Placental hypertrophy, as an adaptation to impaired uterine circulation, is discussed, The mammalian fetus relies almost wholly on the placenta for its nutrition, respiration and excretion. Its rate of growth is thought to be modified by the functional capacity of the placenta however, the possibility that fetal demand may in turn affect the growth and function of the placenta has received little consideration. Yet placental hypertrophy has been observed in chronically anemic women (Beischer et al., 1968) and in rats following acute maternal blood loss (Bruce and Cabral, 1975); conditions in which an increased functional capacity might be needed to compensate for a reduction in blood 02 content or arterial perfusion pressure.