Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate-imipramine combination.
Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate-imipramine combination.
复制标题
DOI：
10.1001/archpsyc.1983.01790220086014
复制
发表时间：
1984-11
影响因子：
--
通讯作者：
R. Prien;D. Kupfer;P. Mansky;J. Small;Vincente B. Tuason;C. Voss;Wayne E. Johnson
中科院分区：
文献类型：
--
作者：
R. Prien;D. Kupfer;P. Mansky;J. Small;Vincente B. Tuason;C. Voss;Wayne E. Johnson
在一项双盲、长期随访研究中，117名双相情感障碍患者接受碳酸锂、盐酸丙咪嗪或两者联合治疗，150名单极情感障碍患者接受碳酸锂、丙咪嗪、碳酸锂和丙咪嗪或安慰剂治疗。对于双相患者，碳酸锂和联合治疗在预防躁狂复发方面优于丙咪嗪，在预防躁狂复发方面与丙咪嗪一样有效，在预防抑郁发作方面与丙咪嗪一样有效。组合处理没有提供优于单独碳酸锂的优点。对于单相患者，丙咪嗪和联合治疗在预防抑郁复发方面比碳酸锂和安慰剂更有效。联合治疗与丙咪嗪单独治疗相比没有优势。碳酸锂治疗组的躁狂发作比其他组少。主要根据重度抑郁或躁狂发作的发生率评价治疗结局，其与指标发作（即，将患者纳入研究的发作）的特征显著相关。
In a double-blind, long-term follow-up study, 117 bipolar patients received lithium carbonate, imipramine hydrochloride, or both and 150 unipolar patients received lithium carbonate, imipramine, both lithium carbonate and imipramine, or placebo. With bipolar patients, lithium carbonate and the combination treatment were superior to imipramine in preventing manic recurrences and were as effective as imipramine in preventing manic recurrences and were as effective as imipramine in preventing depressive episodes. The combination treatment provided no advantage over lithium carbonate alone. With unipolar patients, imipramine and the combination treatment were more effective than lithium carbonate and placebo in preventing depressive recurrences. The combination treatment provided no advantage over imipramine alone. The lithium carbonate-treated group had fewer manic episodes than the other groups. Treatment outcome, which was evaluated primarily in terms of the occurrence of major depression or manic episodes, was significantly related to characteristics of the index episode, ie, the episode that brought the patient into the study.