Self-assembling small-molecule adjuvants as antigen nano-carriers
Self-assembling small-molecule adjuvants as antigen nano-carriers
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自组装小分子佐剂作为抗原纳米载体
DOI：
10.1039/d2cc05016a
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发表时间：
2022
影响因子：
4.9
通讯作者：
Uesugi Motonari
中科院分区：
文献类型：
--
作者：
Jin Shuyu;Zhuo Shao-hua;Takemoto Yasushi;Li Yan-mei;Uesugi Motonari
抗原和免疫增强剂(佐剂)的有效共传递和高度的抗原提呈一直是亚单位疫苗发展中的两大挑战。在这里，我们通过将多肽抗原与胆酸胺(一种自组装小分子佐剂)相结合来解决这些问题。偶联物和胆碱酰胺的共同组装实现了高水平的细胞因子诱导和MHC II类肽呈递。
The effective co-delivery of antigens and immune potentiators (adjuvants) and the high degree of antigen presentation have been two major challenges in the development of subunit vaccines. Here, we address these issues by conjugating peptide antigens with cholicamide, a self-assembling small molecule adjuvant. Co-assemblies of the conjugates and cholicamide achieved high levels of both cytokine induction and MHC class II peptide presentation.