Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study
Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study
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DOI：
10.1007/s00535-012-0533-z
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发表时间：
2012-05-01
影响因子：
6.3
通讯作者：
Saibara, Toshiji
中科院分区：
文献类型：
--
作者：
Eguchi, Yuichiro;Hyogo, Hideyuki;Saibara, Toshiji
非酒精性脂肪性肝病（NAFLD）的患病率一直在增加。本研究旨在评估NAFLD的近期患病率，并使用已建立的评分系统预测普通人群中非酒精性脂肪性肝炎（NASH）伴肝纤维化的患病率，对2009年至2010年在日本3家健康中心接受健康检查的8352名受试者进行了横断面研究。排除摄入酒精超过20 g/天或患有其他慢性肝病的受试者。超声检查发现脂肪肝。根据体重指数、年龄、ALT和甘油三酯（BAAT）以及FIB-4（基于年龄、天冬氨酸转氨酶和丙氨酸转氨酶水平以及血小板计数）指标计算NASH伴晚期纤维化的概率。NAFLD的总患病率为29.7%。男性（41.0%）和女性（17.7%）之间的平均患病率有三倍的显著差异。无论阈值如何，即使没有肥胖，这种患病率也随体重指数、甘油三酯和低密度脂蛋白胆固醇呈线性增加。根据BAAT指数a/千日元3估计NASH患病率为2.7%，根据FIB-4指数估计患病率为1.9%.NAFLD的患病率在一般人群中有所增加，尤其是在男性中。NAFLD的患病率与各种代谢参数之间存在线性关系，即使在非肥胖受试者中也是如此。据估计，NASH伴晚期纤维化的患病率在NAFLD受试者中相当高。
The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to assess the recent prevalence of NAFLD and to predict the prevalence of nonalcoholic steatohepatitis (NASH) with liver fibrosis using established scoring systems in the general population.A cross-sectional study was conducted among 8352 subjects who received health checkups from 2009 to 2010 in three health centers in Japan. Subjects with an intake over 20 g of alcohol/day or with other chronic liver diseases were excluded. Fatty liver was detected by ultrasonography. The probability of NASH with advanced fibrosis was calculated according to the body mass index, age, ALT, and triglyceride (BAAT) and FIB-4 (based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet counts) indices.A total of 5075 subjects were enrolled. The overall prevalence of NAFLD was 29.7%. There was a significant threefold difference in the mean prevalence between males (41.0%) and females (17.7%). This prevalence showed a linear increase with body mass index, triglycerides, and low-density lipoprotein cholesterol regardless of threshold values, even without obesity. The estimated prevalence of NASH according to the BAAT index a parts per thousand yen3 was 2.7%, and according to the FIB-4 index it was 1.9%.The prevalence of NAFLD has increased in the general population, especially in males. There is a linear relationship between the prevalence of NAFLD and various metabolic parameters, even in nonobese subjects. The prevalence of NASH with advanced fibrosis is estimated to be considerably high in subjects with NAFLD.