Taurine decreased uric acid levels in hyperuricemic rats and alleviated kidney injury
Taurine decreased uric acid levels in hyperuricemic rats and alleviated kidney injury
复制标题
牛磺酸降低高尿酸血症大鼠的尿酸水平并减轻肾损伤
DOI：
10.1016/j.bbrc.2017.05.139
复制
发表时间：
2017-07-29
影响因子：
3.1
通讯作者：
Hu, Jianmin
中科院分区：
文献类型：
--
作者：
Feng, Ying;Sun, Fang;Hu, Jianmin
高尿酸血症可导致直接的肾脏损害。牛磺酸参与多种肾脏生理过程，并已被证明是一种肾脏保护剂。有报道牛磺酸可以降低糖尿病大鼠的尿酸水平，但迄今为止尚无牛磺酸对肾损伤的高尿酸血症大鼠的影响的研究。本研究采用腺嘌呤和盐酸乙胺丁醇灌胃10 d建立高尿酸血症大鼠模型，并提前7 d在饮水中添加牛磺酸（1%或2%），连续17 d。结果表明，牛磺酸可减轻高尿酸血症大鼠肾脏形态和病理变化以及肾功能障碍。牛磺酸能有效降低高尿酸血症大鼠升高的黄嘌呤氧化酶活性，表明其对尿酸形成的调节作用。尿酸的重吸收和分泌依赖于多种尿酸盐转运蛋白。在高尿酸血症大鼠中，三种尿酸转运蛋白的表达显着下调，而牛磺酸则阻止这些尿酸转运蛋白的 mRNA 和蛋白表达水平的降低。结果表明，牛磺酸可能在调节肾脏尿酸排泄中发挥作用。因此，牛磺酸可能成为治疗高尿酸血症的有前景的药物。 (C) 2017 Elsevier Inc. 保留所有权利。
Hyperuricemia can lead to direct kidney damage. Taurine participates in several renal physiological processes and has been shown as a renoprotective agent. It has been reported that taurine could reduce uric acid levels in diabetic rats, but to date there was no research on the effects of taurine on hyperuricemic rats with kidney injury. In present study, hyperuricemic rat models were induced by intragastric administration of adenine and ethambutol hydrochloride for 10 days, and taurine (1% or 2%) were added in the drinking water 7 days in advance for consecutively 17 days. The results showed that taurine alleviated renal morphological and pathological changes as well as kidney dysfunction in hyperuricemic rats. Taurine could efficiently decrease the elevated xanthine oxidase activities in hyperuricemic rats, indicating its effect on the regulation of uric acid formation. The reabsorption and secretion of uric acid are dependent on a number of urate transporters. Expressions of three urate transporters were significantly down-regulated in hyperuricemic rats, while taurine prevented the decrease of mRNA and protein expression levels of these urate transporters. The results indicate that taurine might play a role in the regulation of renal uric acid excretion. Therefore, taurine could be a promising agent for the treatment of hyperuricemia. (C) 2017 Elsevier Inc. All rights reserved.