Lack of control of hypertension in primary cardiovascular disease prevention in Europe: Results from the EURIKA study
Lack of control of hypertension in primary cardiovascular disease prevention in Europe: Results from the EURIKA study
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DOI：
10.1016/j.ijcard.2016.05.044
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发表时间：
2016-09-01
影响因子：
3.5
通讯作者：
Halcox, Julian P.
中科院分区：
文献类型：
--
作者：
Borghi, Claudio;Tubach, Florence;Halcox, Julian P.
背景资料：在欧洲心血管风险预防和管理研究中评估了不受控制的高血压和明显的顽固性高血压的患病率和相关因素，在欧洲的日常实践中（EURIKA; NCT 00882336）。方法：EURIKA是一项横断面观察性研究，包括12个欧洲国家正在接受心血管疾病一级预防治疗的患者。评估患者是否正在接受高血压治疗（N = 5220）。根据欧洲指南定义血压控制，敏感性分析考虑了患者的年龄和糖尿病状态。结果：在初步分析中，共有2691例（51.6%）高血压未得到控制。与高血压不受控制的风险增加显著相关的因素包括女性（比值比[OR]：2.29; 95%置信区间[CI]：1.93-2.73）、体重指数（BMI; OR/kg/m2：1.03; 95% CI：1.01-1.04）和地理位置。共有749例（14.3%）患者存在明显的顽固性高血压。与明显顽固性高血压风险增加显著相关的因素包括BMI（OR/kg/m2：1.06; 95% CI：1.04-1.08），糖尿病（OR：1.28; 95% CI：1.06-1.53）、他汀类药物的使用（OR：1.36; 95% CI：1.15-1.62）、血清尿酸水平（OR：1.16; 95% CI：1.09-1.23）和地理位置。敏感性分析中也出现了类似的结果。结论：超过50%的高血压患者治疗后血压仍不受控制，14.3%的患者有明显的顽固性高血压。与其他心血管危险因素呈正相关。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Background: The prevalence of and factors associated with uncontrolled hypertension and apparent resistant hypertension were assessed in the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (EURIKA; NCT00882336).Methods: EURIKA was a cross-sectional observational study including patients being treated for the primary prevention of cardiovascular disease in 12 European countries. Patients were assessed if they were being treated for hypertension (N = 5220). Blood pressure control was defined according to European guidelines, with sensitivity analysis taking account of patients' age and diabetes status. Associated factors were assessed using multivariate analysis.Results: In the primary analysis, a total of 2691 patients (51.6%) had uncontrolled hypertension. Factors significantly associated with an increased risk of having uncontrolled hypertension included female sex (odds ratio [OR]: 2.29; 95% confidence interval [CI]: 1.93-2.73), body mass index (BMI; OR per kg/m(2): 1.03; 95% CI: 1.01-1.04), and geographic location. A total of 749 patients (14.3%) had apparent resistant hypertension. Factors significantly associated with an increased risk of having apparent resistant hypertension included BMI (OR per kg/m(2): 1.06; 95% CI: 1.04-1.08), diabetes (OR: 1.28; 95% CI: 1.06-1.53), use of statins (OR: 1.36; 95% CI: 1.15-1.62), serum uric acid levels (OR: 1.16; 95% CI: 1.09-1.23), and geographic location. Similar results were seen in sensitivity analyses.Conclusions: Over 50% of patients treated for hypertension continued to have uncontrolled blood pressure and 14.3% had apparent resistant hypertension. Positive associations were seen with other cardiovascular risk factors. (C) 2016 Elsevier Ireland Ltd. All rights reserved.