Ovine placental lactogen concentrations during premature delivery induced by infusion of dexamethasone or adrenocorticotrophin to the fetus.
Ovine placental lactogen concentrations during premature delivery induced by infusion of dexamethasone or adrenocorticotrophin to the fetus.
复制标题
向胎儿输注地塞米松或促肾上腺皮质激素引起的早产期间羊胎盘催乳素浓度。
作者：
M. Taylor;J. Robinson;G. Jenkin;G. Thorburn
在妊娠124 - 129天，12只母羊携带完整（n = 7）或去垂体（n = 5）单胎，通过胎儿内输注地塞米松或（1-24）促肾上腺皮质激素（ACTH）诱导早产。采用特异性放射免疫法测定早产前后母体血浆中绵羊胎盘乳原（oPL）的含量。在母羊分娩前，携带完整或去垂体胎儿的母羊的oPL浓度没有显著变化。结果表明，产前oPL下降并不是分娩的必要前提，胎儿糖皮质激素并不是自然分娩时观察到的oPL浓度下降的直接原因。
Premature delivery was induced by intrafetal infusion of dexamethasone or (1-24)ACTH, starting between days 124 and 129 of pregnancy in twelve ewes carrying intact (n = 7) or hypophysectomized (n = 5) single fetuses. Concentrations of ovine placental lactogen (oPL) in maternal plasma were measured by specific radioimmunoassay before and during premature delivery. There was no significant change in oPL concentrations before delivery in ewes carrying either intact or hypophysectomized fetuses. The results suggest that a prepartum decline in oPL is not an essential prerequisite for delivery, and indicate that fetal glucocorticoids are not directly responsible for the prepartum fall in oPL concentrations observed at spontaneous delivery.