Polygenic risk for hypertriglyceridemia is attenuated in high-fitness men.
Polygenic risk for hypertriglyceridemia is attenuated in high-fitness men.
复制标题
在高健康水平的男性中，高甘油三酯血症的多基因风险会降低。
DOI：
10.1152/physiolgenomics.00182.2013
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Higuchi M.
中科院分区：
文献类型：
--
作者：
Tanisawa K;Ito T;Sun XM;Cao ZB;Sakamoto S;Tanaka M;Higuchi M.
高心肺健康 (CRF) 与血脂异常风险降低相关；然而，血脂水平也受到个体遗传变异的影响。我们进行了一项横断面研究，以确定 CRF 是否可以改变血脂异常的多基因风险。研究人员测量了 170 名日本男性（年龄 20-79 岁）的甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL-C) 和高密度脂蛋白胆固醇 (HDL-C) 的血清水平。通过测量最大摄氧量（V̇o2max）来评估CRF，并根据日本健康促进参考V̇o2max值将受试者分为低体能组和高体能组。我们分析了 19 个与 TG、LDL-C 或 HDL-C 水平相关的单核苷酸多态性 (SNP)。基于这些SNP，我们计算了三种遗传风险评分（GRS：TG-GRS、LDL-GRS和HDL-GRS），并根据每个GRS的三分位将受试者分为低、中、高组。高TG-GRS组和中TG-GRS组低适应度个体血清TG水平均高于低TG-GRS组（分别P<0.01和P<0.05），而高TG-GRS组间高适应度个体TG水平无差异。相比之下，无论健康水平如何，高LDL-GRS组的LDL-C水平高于低LDL-GRS组，高HDL-GRS组的HDL-C水平低于低HDL-GRS组（P<0.05）。这些结果表明，高 CRF 可以降低高甘油三酯血症的多基因风险；然而，高 CRF 可能无法改变日本男性与高 LDL-C 和低 HDL-C 水平相关的多基因风险。
High cardiorespiratory fitness (CRF) is associated with a reduced risk for dyslipidemia; however, blood lipid levels are also affected by individual genetic variations. We performed a cross-sectional study to determine whether CRF modifies polygenic risk for dyslipidemia. Serum levels of triglycerides (TG), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C) were measured in 170 Japanese men (age 20–79 yr). CRF was assessed by measuring maximal oxygen uptake (V̇o2max), and subjects were divided into low-fitness and high-fitness groups according to the reference V̇o2maxvalue for health promotion in Japan. We analyzed 19 single nucleotide polymorphisms (SNPs) associated with TG, LDL-C, or HDL-C levels. Based on these SNPs, we calculated three genetic risk scores (GRSs: TG-GRS, LDL-GRS, and HDL-GRS), and subjects were divided into low, middle, and high groups according to the tertile for each GRS. Serum TG levels of low-fitness individuals were higher in the high and middle TG-GRS groups than in the low TG-GRS group (P< 0.01 andP< 0.05, respectively), whereas no differences were detected in the TG levels of high-fitness individuals among the TG-GRS groups. In contrast, the high LDL-GRS group had higher LDL-C levels than did the low LDL-GRS group, and HDL-C levels were lower in the high HDL-GRS group than in the low HDL-GRS group regardless of the fitness level (P< 0.05). These results suggest that high CRF attenuates polygenic risk for hypertriglyceridemia; however, high CRF may not modify the polygenic risk associated with high LDL-C and low HDL-C levels in Japanese men.