Loss of photoreversibility of sunburn cell induction in Monodelphis domestica.
Loss of photoreversibility of sunburn cell induction in Monodelphis domestica.
复制标题
Monodelphis Domestica 晒伤细胞诱导的光可逆性丧失。
DOI：
10.1111/j.1751-1097.1987.tb04773.x
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发表时间：
1987
影响因子：
3.3
通讯作者：
Applegate,LA
中科院分区：
文献类型：
--
作者：
Ley,RD;Applegate,LA
南美负鼠Monodelphis home tica暴露在紫外线辐射(UVR)下，可在表皮形成晒伤细胞(SBCs)。然而，如果在紫外线照射后立即暴露于光再激活光，这将逆转紫外线诱导的表皮∼中95%的吡咯烷二聚体，SBCS的出现被∼90%抑制。延迟光复活(PR)处理会导致PR处理抑制SBC诱导的能力随着时间的推移而逐渐丧失。紫外线照射12h后给予PR处理，仅对SBC的形成有∼11%的抑制作用，尽管PR照射可修复∼97%的嘧啶二聚体。
Exposure of the South American opossum,Monodelphis domestica, to ultraviolet radiation (UVR) resulted in the formation of sunburn cells (SBCs) in the epidermis. If, however, the UVR was immediately followed by an exposure to photoreactivating light, which reversed ∼ 95% of the UVR‐induced pyrrolidine dimers in epidermal DNA, the appearance of SBCs was suppressed by ∼ 90%. Delaying the photoreactivation (PR) treatment resulted in a progressive loss with time in the capacity of the PR treatment to suppress SBC induction. PR treatment administered 12 h after UVR exposure resulted in only an ∼ 11% suppression of SBC formation even though ∼ 97% of the remaining pyrimidine dimers were repaired by the PR exposure.