The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
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DOI：
10.1136/annrheumdis-2013-204763
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发表时间：
2014-07-01
影响因子：
27.4
通讯作者：
March, Lyn
中科院分区：
文献类型：
--
作者：
Cross, Marita;Smith, Emma;March, Lyn
目的评估髋关节和膝关节骨关节炎（OA）的全球负担，作为全球疾病负担2010年研究的一部分，并探讨髋关节和膝关节OA的负担如何与其他conditions.Methods进行系统评价，以获得髋关节和膝关节OA患病率，发病率和死亡风险的年龄特异性和性别特异性流行病学数据。包括症状性、影像学和自我报告的髋关节或膝关节OA的患病率和发生率。定义了三个严重程度级别，以得出残疾权重（DW）和严重程度分布（轻度、中度和重度OA的比例）。将国家和地区的患病率乘以严重程度分布和适当的残疾权重，以计算残疾生活年数（YLD）。由于没有直接归因于OA的死亡，YLDs等于残疾调整生命年（DSDs）。结果在全球范围内，在291种疾病中，髋关节和膝关节OA是全球残疾的第11大贡献者，在DSDs中排名第38位。膝关节OA的全球年龄标准化患病率为3.8%（95%不确定区间（UI）为3.6%至4.1%），髋关节OA为0.85%（95% UI为0.74%至1.02%），1990年至2010年无明显变化。女性患病率高于男性。髋关节和膝关节OA的YLD从1990年的1050万例（占总残疾人数的0.42%）增加到2010年的1710万例（占总残疾人数的0.69%）。本研究中的方法学问题使得OA的真实的负担很可能被低估了。随着世界人口的老龄化和日益肥胖，卫生专业人员需要为治疗髋关节和膝关节OA的卫生服务需求的大幅增加做好准备。
Objective To estimate the global burden of hip and knee osteoarthritis (OA) as part of the Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA compares with other conditions.Methods Systematic reviews were conducted to source age-specific and sex-specific epidemiological data for hip and knee OA prevalence, incidence and mortality risk. The prevalence and incidence of symptomatic, radiographic and self-reported hip or knee OA were included. Three levels of severity were defined to derive disability weights (DWs) and severity distribution (proportion with mild, moderate and severe OA). The prevalence by country and region was multiplied by the severity distribution and the appropriate disability weight to calculate years of life lived with disability (YLDs). As there are no deaths directly attributed to OA, YLDs equate disability-adjusted life years (DALYs).Results Globally, of the 291 conditions, hip and knee OA was ranked as the 11th highest contributor to global disability and 38th highest in DALYs. The global age-standardised prevalence of knee OA was 3.8% (95% uncertainty interval (UI) 3.6% to 4.1%) and hip OA was 0.85% (95% UI 0.74% to 1.02%), with no discernible change from 1990 to 2010. Prevalence was higher in females than males. YLDs for hip and knee OA increased from 10.5 million in 1990 (0.42% of total DALYs) to 17.1 million in 2010 (0.69% of total DALYs).Conclusions Hip and knee OA is one of the leading causes of global disability. Methodological issues within this study make it highly likely that the real burden of OA has been underestimated. With the aging and increasing obesity of the world's population, health professions need to prepare for a large increase in the demand for health services to treat hip and knee OA.