Chronic exercise increases sensitivity to the conditioned rewarding effects of cocaine.
Chronic exercise increases sensitivity to the conditioned rewarding effects of cocaine.
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发表时间：
2008-07
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通讯作者：
Mark A. Smith;Samantha R Gergans;J. Iordanou;M. A. Lyle
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作者：
Mark A. Smith;Samantha R Gergans;J. Iordanou;M. A. Lyle
本研究的目的是确定长期运动是否会改变可卡因条件奖励效应的敏感性。在断奶时获得雌性大鼠，并随机分配到久坐或运动条件下。在这些条件下6周后，在条件性位置偏爱程序中检查可卡因的作用。在这两组大鼠中，可卡因产生了剂量依赖性的条件性位置偏爱。在这个过程中，运动大鼠比久坐不动的大鼠对可卡因更敏感，这种效果在最高剂量的可卡因时最为明显。这些数据表明，长期运动增加了对可卡因条件奖励效应的敏感性。
The purpose of this study was to determine whether chronic exercise alters sensitivity to the conditioned rewarding effects of cocaine. Female rats were obtained at weaning and randomly assigned to either sedentary or exercise conditions. After 6 weeks under these conditions, the effects of cocaine were examined in the conditioned place preference procedure. Cocaine produced a dose-dependent conditioned place preference in both groups of rats. Exercising rats were more sensitive than sedentary rats to cocaine in this procedure, and this effect was most pronounced at the highest dose of cocaine. These data suggest that chronic exercise increases sensitivity to the conditioned rewarding effects of cocaine.