Incidence of thrombophilia detected in southern Taiwanese patients with venous thrombosis
Incidence of thrombophilia detected in southern Taiwanese patients with venous thrombosis
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DOI：
10.1007/s00277-002-0603-z
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发表时间：
2003-02-01
影响因子：
3.5
通讯作者：
Tsao, CJ
中科院分区：
文献类型：
--
作者：
Chen, TY;Su, WC;Tsao, CJ
为了分析台湾南部地区血栓形成倾向的发生率，我们研究了56例年龄小于或等于65岁的深静脉血栓形成（DVT）患者的抗凝血酶（AT）、蛋白C（PC）和蛋白S（PS）缺陷的患病率，凝血因子V Leiden突变的患病率，以及获得性狼疮抗凝物（LA）和抗心磷脂抗体（ACA）的存在。56例患者中，男性30例，女性26例，平均年龄43岁（18-65岁）。21例患者（37.5%）显示异常结果：4例（7.1%）AT缺乏，6例（10.7%）PC缺乏，6例（10.7%）PS缺乏，2例（3.6%）PC和PS联合缺乏，3例（5.4%）LA和ACA。仅PC和PS缺陷与血栓形成风险增加显著相关，比值比分别为4.2（95%置信区间：1.2-15.0，P=0.018）和8.1（95%置信区间：1.6-40.6，P=0.003）。我们的结论是，台湾遗传性血栓形成倾向的患病率（34.0%）高于西方国家，但低于香港和台湾以前的报告。我们把这归因于选择偏差。
In order to analyze the incidence of thrombophilia in southern Taiwan, we studied the prevalence of antithrombin (AT), protein C (PC), and protein S (PS) deficiencies, the prevalence of factor V Leiden mutation, and the presence of acquired lupus anticoagulant (LA) and anticardiolipin antibody (ACA) in 56 patients less than or equal to65 years old with deep venous thrombosis (DVT). Of 56 patients, 30 were male, 26 female, and the mean age of the patients was 43 years (18-65 years). None had factor V mutation or activated PC resistance; 21 patients (37.5%) showed abnormal results: 4 (7.1%) had AT deficiencies, 6 (10.7%) PC deficiencies, 6 (10.7%) PS deficiencies, 2 (3.6%) a combined PC and PS deficiency, and 3 (5.4%) LA and ACA. Only PC and PS deficiencies were significantly associated with increased risk for the development of thrombosis with an odds ratio of 4.2 (95% confidence interval: 1.2-15.0, P=0.018) and 8.1 (95% confidence interval: 1.6-40.6, P=0.003), respectively. We concluded that the prevalence of heritable thrombophilia (34.0%) in Taiwan is higher than that in Western countries, but that it is lower than previously reported in Hong Kong and Taiwan. We attribute this to selection bias.