Impaired sleep quality and restless legs syndrome in idiopathic focal dystonia: a controlled study
Impaired sleep quality and restless legs syndrome in idiopathic focal dystonia: a controlled study
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DOI：
10.1007/s00415-011-6029-6
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发表时间：
2011-10-01
影响因子：
6
通讯作者：
Abele, Michael
中科院分区：
文献类型：
--
作者：
Paus, Sebastian;Gross, Jennifer;Abele, Michael
虽然睡眠障碍在帕金森氏病和其他基底节疾病中很常见，但有关肌张力障碍的睡眠障碍的信息仅限于泛型或Segawa病。尽管许多患有特发性颈肌张力障碍(CD)和眼睑痉挛(BL)的患者报告睡眠不佳，但没有关于频率或与抑郁和疼痛等众所周知的症状相互作用的数据。采用标准化访谈和评估工具、临床检查和自我评定表，对221例CD和BL患者和93例神经科健康对照进行了研究。44%的CD患者、46%的BL患者和20%的对照组存在睡眠质量受损。在肌张力障碍患者中，它与抑郁症状(26%；P<；0.001)和不宁腿综合症(19%；P<；0.01)有关。磨牙症(在CD；P<；0.001)和女性(在Bl；p<；0.001)被确定为进一步的危险因素，但不是肌张力障碍症状的严重程度。CD和BL患者白天嗜睡较少(6%)。睡眠质量受损在局灶性肌张力障碍中很常见，频率为45%，并与抑郁、磨牙症和RLS症状相关。CD和BL患者的结果相似，表明睡眠障碍的内在机制，而不是肌张力障碍的直接影响。有必要对局灶性肌张力障碍患者的睡眠进行进一步研究，包括多导睡眠图记录。
While sleep disorders are common in Parkinson's disease and other basal ganglia disorders, information on sleep disturbances in dystonia is limited to generalized forms or Segawa disease. Although many patients with idiopathic cervical dystonia (CD) and blepharospasm (BL) report poor sleep, there are no data on frequency or interactions with well known symptoms like depression and pain. Standardized interviews and assessment instruments, clinical examinations, and self rating forms were applied in 221 patients with CD and BL, and in 93 neurologically healthy controls. Impaired sleep quality was found in 44% of CD patients, 46% of BL patients, and 20% of controls. In dystonia, it was associated with symptoms of depression (frequency of 26%; p < 0.001) and restless legs syndrome (RLS) (frequency of 19%; p < 0.01). Bruxism (in CD; p < 0.05), and female sex (in BL; p < 0.001) were identified as further risk factors, but not severity of dystonic symptoms. Excessive daytime sleepiness was rare in CD and BL (6%). With a frequency of 45%, impairment of sleep quality is common in focal dystonia and associated with symptoms of depression, bruxism, and RLS. Results in CD and BL patients are similar, pointing to an intrinsic mechanism of sleep disturbances rather than a direct effect of dystonic muscle activity. Further studies on sleep in focal dystonia, including polysomnographic recordings, are warranted.