Modifications of cardiac autonomic profile associated with a shift schedule of work
Modifications of cardiac autonomic profile associated with a shift schedule of work
复制标题
DOI：
10.1161/01.cir.102.16.1912
复制
发表时间：
2000-10-17
期刊：
影响因子：
37.8
通讯作者：
Malliani, A
中科院分区：
文献类型：
--
作者：
Furlan, R;Barbic, F;Malliani, A
背景-轮班工作与心血管疾病和事故的发生率增加有关。与压力相关的生物学变量的昼夜节律与工作-睡眠时间表之间的不一致可能解释工作效率的降低。目前尚不清楚轮班工作制是否会引起心脏自主神经控制的24小时振荡模式与工作-睡眠周期的不一致性。方法和结果22名健康男性蓝领轮班工人在3个不同班次中的每一个班次进行了24小时ECG记录（第一，上午6点到下午2点;第二，下午2点到10点;第三，下午10点到上午6点）。24小时心率变异性的频谱分析提供了心脏交感神经（LFnu）和迷走神经（HFnu）对窦房结活动和交感迷走神经平衡（LF/HF）的调节的标准化标志物，LFnu和LF/HF表现出24小时振荡，其最大和最小时间分别与工作和睡眠时间一致。较低的值LFnu和LF/HF提示减少心脏交感神经调制时，工作任务是在夜间进行的值相比，观察到的值时，在早上和晚上进行的工作。结论-连续每周的变化的时间最大和最小的心脏交感神经和迷走神经自主控制可能发挥作用，在过度的心血管疾病率在轮班工人，夜间工作时心脏交感神经调节指数的降低可能与困倦或警觉性降低有关，这反过来又可能促进错误和事故。
Background-Shift work is associated with an increased rate of cardiovascular diseases and accidents. Discordance between circadian rhythms of stress-related biological variables and the work-sleep schedule might explain the reduced efficiency of work. It is not clear whether a shift schedule of work may induce similar discordance in the 24-hour oscillatory pattern of the cardiac autonomic control in respect to the work-sleep periods.Methods and Results-Twenty-two healthy male blue-collar shift workers underwent 24-hour ECG recordings during each of the 3 different shifts (first, 6 AM to 2 PM; second, 2 to 10 PM; third, 10 PM to 6 AM). Spectral analysis of heart rate variability over 24 hours provided the normalized markers of cardiac sympathetic (LFnu) and vagal (HFnu) modulation of the sinoatrial node activity and of the sympathovagal balance (LF/HF), LFnu and LF/HF exhibited 24-hour oscillations with different times of maximum and minimum in accordance with the working and sleeping periods, respectively. Lower values of LFnu and LF/HF suggestive of a reduced cardiac sympathetic modulation were present when the job task was performed at night compared with the values observed when the work was performed during morning and evening.Conclusions-Continuous weekly changes of time of maximum and minimum in the cardiac sympathetic and vagal autonomic control may play a role in the excessive rate of cardiovascular diseases in shift workers, The reduced values of the indexes of cardiac sympathetic modulation during night work might be related to the presence of sleepiness or diminished alertness, which in turn could facilitate errors and accidents.