Muscle regeneration in young and old rats: Effects of motor nerve transection with and without Marcaine treatment
Muscle regeneration in young and old rats: Effects of motor nerve transection with and without Marcaine treatment
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DOI：
10.1093/gerona/53a.1.b52
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发表时间：
1998-01-01
影响因子：
5.1
通讯作者：
Faulkner, JA
中科院分区：
文献类型：
--
作者：
Carlson, BM;Faulkner, JA
我们验证了这样一个假设，即与年轻大鼠相比，老年大鼠骨骼肌再生后，运动神经损伤而不是肌纤维损伤决定了肌肉质量和最大力量（P-o）缺陷的程度。比较年轻（4月龄）和年老（24月龄）雄性大鼠在(i)可卡因治疗加同时运动神经横断、（ii）单独运动神经横断和（iii）单独使用可卡因治疗两个月后的指长伸肌（EDL）质量和P-o（来自先前收集的数据）。在单纯神经切断组和吗啡联合神经切断组中，年轻大鼠的质量和P-o的恢复明显大于年老大鼠。这与我们之前的数据相反，我们之前的数据显示，在没有神经损伤的情况下，服用过可卡因的老年大鼠的肌肉再生能力与年轻大鼠一样。我们的假设得到了支持，我们得出的结论是，与年轻大鼠相比，老龄大鼠的轴突再生受损，神经肌肉接触的重建，或两者兼而有之，是肌肉移植再生受损的关键因素。
We tested the hypothesis that after skeletal muscle regeneration in old compared with young rats damage to the motor nerve rather than damage to muscle fibers determines the magnitude of the deficits in muscle mass and maximum force (P-o). The mass and P-o of extensor digitorum longus (EDL) muscles of young (4 months) and old (24 months) male rats were compared two months following (i) Marcaine treatment plus simultaneous motor nerve transection, (ii) motor nerve transection alone, and (iii) Marcaine treatment alone (from data compiled previously). In both the nerve transection-only and Marcaine with nerve transection groups the recovery of mass and P-o was significantly greater in young than in old rats. This is in contrast to our previous data showing that in the absence of nerve damage Marcaine-treated muscle in old rats regenerates as well as that in young rats. Our hypothesis was supported and we conclude that impaired axonal regeneration, re-establishment of nerve-muscle contact, or both, is the critical component in the impaired regeneration of muscle grafts in old as compared with young rats.