Coupling the folding of homologous proteins.
Coupling the folding of homologous proteins.
复制标题
耦合同源蛋白质的折叠。
DOI：
10.1073/pnas.95.11.5880
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发表时间：
1998
影响因子：
11.1
通讯作者：
Skolnick,J
中科院分区：
文献类型：
--
作者：
Keasar,C;Tobi,D;Elber,R;Skolnick,J
利用同源蛋白折叠成相似结构的经验观察，增强了anab initioalgorithm预测蛋白质构象的能力。在电位中加入一个迫使同源蛋白看起来相似的惩罚函数，并将其用于几种同源蛋白的耦合能量优化。在计算结构的质量显著改善（与单个蛋白质的计算折叠相比）被证明和讨论。
The empirical observation that homologous proteins fold to similar structures is used to enhance the capabilities of anab initioalgorithm to predict protein conformations. A penalty function that forces homologous proteins to look alike is added to the potential and is employed in the coupled energy optimization of several homologous proteins. Significant improvement in the quality of the computed structures (as compared with the computational folding of a single protein) is demonstrated and discussed.