OXYTOCIN AUGMENTATION OF DYSFUNCTIONAL LABOR .4. OXYTOCIN PHARMACOKINETICS
OXYTOCIN AUGMENTATION OF DYSFUNCTIONAL LABOR .4. OXYTOCIN PHARMACOKINETICS
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DOI：
10.1016/s0002-9378(84)90355-7
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发表时间：
1984-01-01
影响因子：
9.8
通讯作者：
CASTILLO, M
中科院分区：
文献类型：
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作者：
SEITCHIK, J;AMICO, J;CASTILLO, M
在催产素输注期间每20分钟测量血浆催产素水平（[OT]p）。如有必要，初始剂量为1 mU/min，每隔40 min增加1 mU/min，直至获得足够的收缩力以实现宫颈扩张。在输注的前40分钟，[OT]p随剂量线性上升。在40分钟和60分钟的样品值之间没有差异，这表明在40分钟内达到每个剂量的峰值[OT]p。产生有效收缩性所需的[OT]p的增量在0.58至5.09 μ U/ml之间变化很大。血浆清除率从11.2到32.5 ml/kg/min不等。任何特定剂量的催产素达到“稳态”[OT]p和最大子宫收缩反应需要大约40 min。设计方案的增加或引产应根据这方面的知识。
Plasma oxytocin levels ([OT]p) were measured every 20 min during infusions of oxytocin. The initial dosage of 1 mU/min was incremented, if necessary, by 1 mU/min at 40-min intervals until sufficient contractility was obtained to effect cervical dilatation. The [OT]p rises linearly with dose for the first 40 min of the infusion. There is no difference between the 40- and 60-min sample values, suggesting that the peak [OT]p of each dose is achieved in 40 min. The increment in [OT]p required to produce effective contractility varies widely from 0.58 to 5.09 .mu.U/ml. The plasma clearance rate varied from 11.2 to 32.5 ml/kg per min. Approximately 40 min is required for any particular dose of oxytocin to reach a "steady-state" [OT]p and the maximal uterine contractile response. The design of regimens for the augmentation or induction of labor should be based on this knowledge.