Predicting progression to severe proliferative diabetic retinopathy.
Predicting progression to severe proliferative diabetic retinopathy.
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DOI：
10.1001/archopht.1987.01060060096041
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发表时间：
1987-06
影响因子：
--
通讯作者：
G. Bresnick;M. Palta
中科院分区：
文献类型：
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作者：
G. Bresnick;M. Palta
在参加早期治疗糖尿病视网膜病变研究的85名糖尿病患者中，观察到了视网膜病变的长期进展。对于具有以下基线特征的眼睛，进展为严重视网膜病变的可能性显著更大：视网膜病变总体严重程度更高，荧光素渗漏更高，毛细血管无灌注率更高，视网膜电图振荡电位幅度更低。在回归模型中，振荡电位的总幅度、视网膜病变的总体严重程度和荧光素血管造影渗漏的严重程度被发现是进展为严重增殖性视网膜病变的独立预测因素；当模型中包括荧光素渗漏时，未发现毛细血管无灌注独立预测进展。基于回归模型的概率曲线可以用来支持临床决策，即何时进行全视网膜激光光凝，以及对不严重的增殖性糖尿病视网膜病变患者进行随访的频率。
The longer-term progression of retinopathy was observed in a previously described group of 85 diabetic patients enrolled in the Early Treatment Diabetic Retinopathy Study. The probability of progression to severe retinopathy was significantly greater for eyes with the following baseline characteristics: greater overall retinopathy severity, higher fluorescein leakage, higher capillary nonperfusion, and lower electroretinographic oscillatory potential amplitudes. The summed amplitudes of the oscillatory potentials, the overall severity of retinopathy, and the severity of fluorescein angiographic leakage were found to be independent predictors of progression to severe proliferative retinopathy in a regression model; capillary nonperfusion was not found to predict progression independently when fluorescein leakage was included in the model. Probability curves based on the regression model can be used to support clinical decisions concerning when to perform panretinal laser photocoagulation and how often to follow up patients with less than severe proliferative diabetic retinopathy.