Control of hyperphagia prevents obesity in BDNF heterozygous mice
Control of hyperphagia prevents obesity in BDNF heterozygous mice
复制标题
DOI：
10.1097/00001756-200412030-00022
复制
发表时间：
2004-12-03
期刊：
影响因子：
1.7
通讯作者：
Tessarollo, L
中科院分区：
文献类型：
--
作者：
Coppola, V;Tessarollo, L
小鼠 BDNF 水平降低会导致肥胖和行为异常，包括攻击性增加和多动。虽然已经表明肥胖部分是由食物消耗增加引起的，但仍不清楚涉及体重稳态控制的其他机制的缺陷是否也会影响这种表型。在这里，我们报告说，如果长期喂食对照小鼠通常消耗的食物量，BDNF 水平降低的小鼠不会出现肥胖，并且血糖水平正常。因此，进食过多似乎是肥胖发展的主要原因，而不是控制代谢机制的变化。
Reduced levels of BDNF in mice cause obesity and behavioral abnormalities including increased aggression and hyperactivity. While it has been shown that the obesity is in part caused by increased food consumption it is still not clear whether defects in other mechanisms involved in the control of body weight homeostasis can also affect this phenotype. Here we report that mice with reduced levels of BDNF do not develop obesity and have normal blood glucose levels if fed over a prolonged period of time the amount of food that control mice usually consume. Thus, hyperphagia appears to be the primary cause of obesity development rather than changes in mechanisms controlling metabolism.