Associations of birthweight and history of childhood obesity with beta cell mass in Japanese adults
Associations of birthweight and history of childhood obesity with beta cell mass in Japanese adults
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DOI：
10.1007/s00125-020-05127-2
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发表时间：
2020-04-01
期刊：
影响因子：
8.2
通讯作者：
Itoh, Hiroshi
中科院分区：
文献类型：
--
作者：
Sasaki, Hironobu;Saisho, Yoshifumi;Itoh, Hiroshi
目的/假设低出生体重与糖尿病的高风险相关，但还没有关于人类出生体重和胰腺组织的报道。本研究的目的是检验出生体重与人类β细胞和α细胞质量的相关性。方法64例接受胰腺切除术的日本成年人，有糖尿病和非糖尿病，并且能够回忆他们的体重历史，包括出生体重。胰腺组织行胰岛素和胰升糖素染色，计算胰岛β细胞面积分数(BCA)和胰岛α细胞面积分数(ACA)。结果在无糖尿病的受试者中，出生体重与BCA呈弱正相关(R=0.34，p=0.03)。有儿童肥胖史的儿童BCA高于无肥胖史的儿童(1.78+/-0.74%比0.99+/-0.53%，P=0.01)，剔除儿童肥胖史后，出生体重与BCA的相关系数增加(R=0.51，P<；0.01)。在那些患有糖尿病的人中，出生体重和BCA之间没有相关性。结论：非糖尿病成人出生体重与β细胞质量呈正相关，但与α细胞质量无关，儿童肥胖史可能影响β细胞质量。
Aims/hypothesis Low birthweight is associated with a high risk of diabetes, but there are no reports discussing birthweight and pancreatic tissues in humans. The purpose of this study was to examine the correlation between birthweight and beta and alpha cell mass in humans.Methods Sixty-four Japanese adults with and without diabetes who underwent pancreatectomy and were able to recall their weight history including birthweight were included. Pancreatic tissues were stained for insulin and glucagon, and fractional beta cell area (BCA) and alpha cell area (ACA) were quantified. Islet size and density and beta cell replication were also quantified and their associations with birthweight were evaluated.Results In participants without diabetes, there was a weak positive correlation between birthweight and BCA (R = 0.34, p = 0.03). The group with a history of childhood obesity, but not the group with a history of obesity in adulthood only, showed higher BCA compared with those without a history of obesity (1.78 +/- 0.74% vs 0.99 +/- 0.53%, p = 0.01), and the correlation coefficient between birthweight and BCA increased after excluding those with a history of childhood obesity (R = 0.51, p < 0.01). In those with diabetes, there was no correlation between birthweight and BCA. No correlation was found between birthweight and ACA in either those with or without diabetes.Conclusions/interpretation Birthweight and beta, but not alpha, cell mass are positively correlated in non-diabetic adults, and a history of childhood obesity may affect beta cell mass.