Genetic variants of FOXP3 influence graft survival in kidney transplant patients
Genetic variants of FOXP3 influence graft survival in kidney transplant patients
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DOI：
10.1016/j.humimm.2013.02.008
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发表时间：
2013-06-01
期刊：
影响因子：
2.7
通讯作者：
Baan, Carla C.
中科院分区：
文献类型：
--
作者：
Engela, Anja U.;Boer, Karin;Baan, Carla C.
FOXP3（+）调节性T细胞（T-reg）在控制异体反应性中发挥作用。研究表明，短（GT）(n)双核苷酸重复(=(GT)(16)；L)。本研究回顾性研究了这种（GT）(n) FOXP3基因多态性对移植肾存活的影响。根据FOXP3基因型将599例连续首次肾移植患者（中位随访时间7.7年）分为s基因型组（SG）和l基因型组（LG）。SG在死亡前的一般移植物存活（logrank试验，p = 0.013）和急性排斥反应后的移植物存活（p = 0.021）均优于LG。多因素分析将（GT）(n) FOXP3二核苷酸重复多态性定义为独立因素，并证实SG在移植肾存活方面具有优势（HR = 0.67, 95% CI 0.48-0.94, p = 0.02）。这项基因关联研究确定了FOXP3基因变异对肾移植患者移植物存活的有益影响。(c) 2013年美国组织相容性和免疫遗传学学会。Elsevier Inc.出版。版权所有。
FOXP3(+) regulatory T cells (T-reg) play a role in controlling alloreactivity. It has been shown that short (GT)(n) dinucleotide repeats (=(GT)(16); L). The present study retrospectively investigated the influence of this (GT)(n) FOXP3 gene polymorphism on renal allograft survival. A total of 599 consecutive first-time kidney transplant patients (median follow-up time 7.7 years) were subdivided according to their FOXP3 genotype into the S-genotype group (SG) and the L-genotype group (LG). The SG was superior to the LG in both general graft survival censored for death (logrank test, p = 0.013) and graft survival following acute rejection (p = 0.021). Multivariate analysis defined the (GT)(n) FOXP3 dinucleotide repeat polymorphism as an independent factor and confirmed an advantage for the SG in renal allograft survival (HR = 0.67, 95% CI 0.48-0.94, p = 0.02). This gene association study identified a beneficial effect of FOXP3 genetic variants on graft survival in kidney transplant patients. (c) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.