Hormonal role of adenosine in maintaining patency of the ductus arteriosus in fetal lambs.
Hormonal role of adenosine in maintaining patency of the ductus arteriosus in fetal lambs.
复制标题
腺苷在维持胎羔动脉导管通畅中的激素作用。
DOI：
10.1097/00000658-198508000-00013
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发表时间：
1985
影响因子：
9
通讯作者：
Berne,RM
中科院分区：
文献类型：
--
作者：
MentzerJr,RM;Ely,SW;Lasley,RD;Mainwaring,RD;WrightJr,EM;Berne,RM
内源性释放的腺苷在维持胎儿羔羊动脉导管通畅方面发挥重要作用的假设得到了检验。该研究的设计是（1）确定外源性腺苷对通过动脉导管的血流的影响（如果有的话）；（2）评估动脉血氧分压、循环内源性血浆腺苷浓度和通过动脉导管的血流速率之间的关系。当在氧诱导导管收缩期间施用外源腺苷（5μmoles）时，导管血流量从 101 +/- 6 ml/min 增加到 153 +/- 4 ml/min（p 小于 0.01）。当在非通气和 100% 氧气通气期间测量胎儿血液腺苷浓度时，内源性腺苷浓度降至预防水平的一半以下，即从 1.12 +/- 0.17 至 0.49 +/- 0.03 microM（p 小于 0.01）。最后，当胎羔用增加的氧气浓度（0%、10%、20%、60%和100%）进行通气并在每个水平同时进行测量时，PO2的上升、血浆腺苷浓度的下降和导管血流量的下降之间存在显着的单指数关系。这些数据表明：（1）腺苷是氧诱导血管收缩过程中羔羊动脉导管的有效血管舒张剂； (2)当PO2增加时，胎儿内源性血浆腺苷水平显着下降； (3)腺苷浓度的下降与导管血流量的减少同时发生。研究结果表明，内源性血管扩张剂腺苷在维持子宫导管通畅方面发挥着重要作用。图片
The hypothesis that endogenously released adenosine plays an important role in maintaining patency of the fetal lamb ductus arteriosus was tested. The design of the study was (1) to determine the effect, if any, of exogenous adenosine on blood flow through the ductus arteriosus and (2) to evaluate the relationship among the partial pressure of oxygen in arterial blood, circulating endogenous plasma adenosine concentration, and the rate of blood flow through the ductus. When exogenous adenosine (5 mumoles) was administered during oxygen-induced ductal constriction, ductal blood flow increased from 101 +/- 6 ml/min to 153 +/- 4 ml/min (p less than 0.01). When fetal blood adenosine concentrations were measured during nonventilation and ventilation with 100% oxygen, endogenous adenosine concentrations fell to less than one-half of the preventilation levels, i.e., from 1.12 +/- 0.17 to 0.49 +/- 0.03 microM (p less than 0.01). Finally, when fetal lambs were ventilated with increasing concentrations of oxygen (0%, 10%, 20%, 60%, and 100%) and measurements obtained simultaneously at each level, there was a significant monoexponential relationship among the rise in PO2, the fall in plasma adenosine concentration, and the decrease in ductal blood flow. These data suggest that: (1) adenosine is a potent vasodilator of the lamb ductus arteriosus during oxygen-induced vasoconstriction; (2) fetal endogenous plasma adenosine levels fall significantly when PO2 is increased; and (3) the fall in adenosine concentrations parallels a decrease in ductal blood flow. The findings suggest that the endogenous vasodilator adenosine plays an important role in maintaining ductal patency in utero. Images