MOLECULAR DESIGN OF A CHIRAL LEWIS ACID FOR THE ASYMMETRIC CLAISEN REARRANGEMENT
MOLECULAR DESIGN OF A CHIRAL LEWIS ACID FOR THE ASYMMETRIC CLAISEN REARRANGEMENT
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不对称克莱森重排的手性路易斯酸的分子设计
DOI：
10.1021/ja00108a048
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发表时间：
1995
影响因子：
15
通讯作者：
Hisashi Yamamoto
中科院分区：
文献类型：
--
作者：
K. Maruoka;S. Saito;Hisashi Yamamoto
'' BuLi，TMEDA.醚; Br 2。'ArMgBr. NiCl 2（dppp）2，乙醚。7jBBr3，CH2C！2.（2，6-二苯基苯酚盐）（MAPH）5在相似的反应条件下（75%产率; 5 ∶ 1）在化学产率和选择性方面给出了较不令人满意的结果。对于烯丙基乙烯基醚底物1（R1= Bu; R2= Bu）的铝促进的克莱森重排也观察到类似的趋势。
''BuLi, TMEDA. ether; Br2.'ArMgBr. NiCl2 (dppp) 2, ether. 7jBBr3, CH2C! 2.(2, 6-diphenylphenoxide)(MAPH) 5 gave less satisfactory results in terms of both chemical yield and selectivity under similar reaction conditions (75% yield; 5: 1). A similar tendency was also observed for the aluminum-promoted Claisen rearrangement of allyl vinyl ether substrate 1 (R1= Bu; R2=