Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: Relation to apolipoprotein E polymorphism
Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: Relation to apolipoprotein E polymorphism
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DOI：
10.1212/wnl.46.2.413
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发表时间：
1996-02-01
期刊：
影响因子：
9.9
通讯作者：
Riekkinen, PJ
中科院分区：
文献类型：
--
作者：
Lehtovirta, M;Soininen, H;Riekkinen, PJ
Alzheimer's disease (AD) is a heterogeneous entity presenting as sporadic and familial disease. In familial AD, there is evidence for genetic linkage to a yet undefined gene on chromosome 14 in early-onset pedigrees and on chromosome 19 in late-onset pedigrees. In a few early-onset kindreds, there were mutations in the amyloid precursor gene on chromosome 21. There is an increased frequency of apolipoprotein E (ApoE) epsilon 4 allele in patients with late-onset AD. We studied the clinical presentation and profile of cognitive deficits in 58 AD patients at the early stage of the disease. We divided the AD patients into subgroups of sporadic late-onset (SLO) (greater than or equal to 65 years), familial late-onset (FLO) (greater than or equal to 65 years), sporadic early-onset (SEO) (
