Reduced functional integration of the sensorimotor and language network in rolandic epilepsy
Reduced functional integration of the sensorimotor and language network in rolandic epilepsy
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DOI：
10.1016/j.nicl.2013.01.004
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发表时间：
2013-01-01
影响因子：
4.2
通讯作者：
Backes, Walter H.
中科院分区：
文献类型：
--
作者：
Besseling, Rene M. H.;Jansen, Jacobus F. A.;Backes, Walter H.
简介：在过去的几年里，越来越多的证据表明罗兰癫痫（RE）与严重的认知共病有关，包括语言障碍。然而，罗兰区（感觉运动区）癫痫样活动影响语言系统的大脑机制尚不清楚。为了调查这一点，罗兰区和区域之间的连接，参与语言处理的研究，使用功能磁共振成像（fMRI）。材料和方法：fMRI数据采集从22名儿童罗兰癫痫和22个年龄匹配的对照组（年龄范围：8-14岁），无论是在休息和使用单词生成和阅读任务。激活图分析显示无组间差异（FWE校正，p
Introduction: Over the last years, evidence has accumulated that rolandic epilepsy (RE) is associated with serious cognitive comorbidities, including language impairment. However, the cerebral mechanism through which epileptiform activity in the rolandic (sensorimotor) areas may affect the language system is unknown. To investigate this, the connectivity between rolandic areas and regions involved in language processing is studied using functional MRI (fMRI).Materials and methods: fMRI data was acquired from 22 children with rolandic epilepsy and 22 age-matched controls (age range: 8-14 years), both at rest and using word-generation and reading tasks. Activation map analysis revealed no group differences (FWE-corrected, p