Activity-dependent cortical target selection by thalamic axons
Activity-dependent cortical target selection by thalamic axons
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DOI：
10.1126/science.281.5376.559
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发表时间：
1998-07-24
期刊：
影响因子：
56.9
通讯作者：
Shatz, CJ
中科院分区：
文献类型：
--
作者：
Catalano, SM;Shatz, CJ
发育中的神经系统中的连接被认为最初是由轴突寻路和目标选择的独立于活动的过程形成的，随后由神经活动细化。在猫从外侧膝状体核（LCN）的轴突选择视皮层作为其靶点的过程中，早期通过颅内灌注河豚毒素阻断钠动作电位改变了这种丘脑皮质投射的模式和精度。大多数的LCN神经元，而不是投射到视觉皮层，阐述了一个显着的投影内的subplate的皮质区通常绕过。那些投射到正确目标的轴突在地形上是混乱的。因此，当丘脑轴突穿过基板时，需要神经活动来进行最初的靶向决定，
Connections in the developing nervous system are thought to be formed initially by an activity-independent process of axon pathfinding and target selection and subsequently refined by neural activity. Blockade of sodium action potentials by intracranial infusion of tetrodotoxin in cats during the early period when axons from the Lateral geniculate nucleus (LCN) were in the process of selecting visual cortex as their target altered the pattern and precision of this thalamocortical projection. The majority of LCN neurons, rather than projecting to visual cortex, elaborated a significant projection within the subplate of cortical areas normally bypassed. Those axons that did project to their correct target were topographically disorganized. Thus, neural activity is required for initial targeting decisions made by thalamic axone as they traverse the subplate,