Visual Interhemispheric and Striate-Extrastriate Cortical Connections in the Rabbit: A Multiple Tracer Study.
Visual Interhemispheric and Striate-Extrastriate Cortical Connections in the Rabbit: A Multiple Tracer Study.
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DOI：
10.1155/2015/591245
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发表时间：
2015
影响因子：
1.5
通讯作者：
Olavarria JF
中科院分区：
文献类型：
--
作者：
Andelin AK;Bruning DJ;Felleman DJ;Olavarria JF
以前的研究在兔子中确定了一系列的纹外皮质区解剖连接V1，但没有描述其内部的地形。为了解决这个问题，我们将多种解剖示踪剂注射到同一只动物的V1的不同区域，并参考扁平皮质的切线部分中显示的胼胝体连接和脊髓结构的模式，分析了由此产生的纹外标记区域的地形。我们的研究结果扩展了以前的研究，并提供了进一步的证据，兔纹外区类似的视觉区在大鼠和小鼠不仅在其一般位置相对于V1，但也在其内部地形。此外，在兔子的纹外区保持一个恒定的关系与脊髓结构的边界和特征的胼胝体图案。这些发现突出了兔子作为大鼠和小鼠的替代模型，以促进我们对哺乳动物皮层视觉处理的理解，特别是对于受益于更大大脑的项目。
Previous studies in rabbits identified an array of extrastriate cortical areas anatomically connected with V1 but did not describe their internal topography. To address this issue, we injected multiple anatomical tracers into different regions in V1 of the same animal and analyzed the topography of resulting extrastriate labeled fields with reference to the patterns of callosal connections and myeloarchitecture revealed in tangential sections of the flattened cortex. Our results extend previous studies and provide further evidence that rabbit extrastriate areas resemble the visual areas in rats and mice not only in their general location with respect to V1 but also in their internal topography. Moreover, extrastriate areas in the rabbit maintain a constant relationship with myeloarchitectonic borders and features of the callosal pattern. These findings highlight the rabbit as an alternative model to rats and mice for advancing our understanding of cortical visual processing in mammals, especially for projects benefiting from a larger brain.