Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or wiithout chromosome 8p allelic imbalance
Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or wiithout chromosome 8p allelic imbalance
复制标题
DOI：
10.1002/pros.20086
复制
发表时间：
2004-09-15
期刊：
影响因子：
2.8
通讯作者：
Petros, JA
中科院分区：
文献类型：
--
作者：
Zhou, W;Goodman, M;Petros, JA
背景识别前列腺癌患者术后疾病复发的风险是一个重要的临床问题。现有的病理学指标只能在一定程度上预测疾病复发，需要更准确的预测指标。采用“等位基因计数”这一新的实验方法，我们测定了107例乳腺癌切除标本中染色体8 p的等位基因状态。统计分析检查了病理预测因素（Gleason评分、分期、手术切缘等）之间的相关性。8 p等位基因不平衡（8 p AI）与肿瘤复发的关系。8 p AI癌在手术切缘阳性的情况下更容易复发，而8 p保留肿瘤的复发与Gleason评分相关，但与手术切缘无关。我们的研究结果表明，染色体8 p等位基因状态影响前列腺癌复发的“传统”标志物的预测价值。如果得到更大规模研究的证实，这些结果可能具有重要的临床意义。(C)2004 Wiley-Liss，Inc.
BACKGROUND. Identification of prostate cancer patients at risk for postoperative disease recurrence is an important clinical issue. Existing pathological markers can predict disease recurrence only to a certain extent, and there is a need for more accurate predictors.METHODS. Using "counting alleles," a novel experimental method, we determined allelic status of chromosome 8p in 107 prostatectomy specimens. Statistical analyses examined the association between pathologic predictors (Gleason score, stage, surgical margin, etc.) and cancer recurrence in patients with and without 8p allelic imbalance (8p AI),RESULTS. 8p AI cancers were more likely to recur in the presence of a positive surgical margin, whereas recurrence of 8p retaining tumors was associated with the Gleason score, but not with the surgical margin.CONCLUSIONS. Our findings suggest that chromosome 8p allelic status affects the predictive value of "traditional" markers of prostate cancer recurrence. If confirmed by larger studies, these results may have important clinical implications. (C) 2004 Wiley-Liss, Inc.