EXPRESSION OF AIRWAY HYPERREACTIVITY TO ACETYLCHOLINE AS A SIMPLE AUTOSOMAL RECESSIVE TRAIT IN MICE
EXPRESSION OF AIRWAY HYPERREACTIVITY TO ACETYLCHOLINE AS A SIMPLE AUTOSOMAL RECESSIVE TRAIT IN MICE
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DOI：
10.1096/fasebj.2.10.3384240
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发表时间：
1988-07-01
期刊：
影响因子：
4.8
通讯作者：
MITZNER, W
中科院分区：
文献类型：
--
作者：
LEVITT, RC;MITZNER, W
对各种支气管收缩剂的气道反应增加是哮喘的标志之一。遗传和环境的相互依赖似乎决定了气道的这种非特异性高反应性。本研究描述了A/J和C3 H/HeJ近交系小鼠及其后代气道对平滑肌收缩（乙酰胆碱）的直接介导反应的遗传模式。与C3 H/HeJ小鼠相比，A/J小鼠对乙酰胆碱的平均气道反应性高出6倍以上。两种表型很容易区分的基础上，在后代的A/J和C3 H/HeJ小鼠的乙酰胆碱的气道反应。这两种表型被称为高反应性（以A/J菌株命名）和低反应性（以C3 H/HeJ菌株命名）。在（A/J. ×.（C3H/HeJ）F1;（C3H/HeJ）F2; A/J）F1 ×C3 H/HeJ（C3 H/HeJ回交）;和[（A/J ×）C3 H/HeJ）F1 x (C3H/HeJ. A/J）F1] F2与主要控制乙酰胆碱介导的气道反应的单个常染色体隐性基因一致。气道反应中的这种单基因差异完全被阿托品抑制，因此完全由毒蕈碱乙酰胆碱受体介导。
An increased airway response to various bronchoconstricting agents is one of the hallmarks of asthma. An interdependence of heredity and environment appears to determine this nonspecific hyperreactivity of the airways. The present study describes the patterns of inheritance of the airway response to a direct mediator of smooth muscle contraction (acetylcholine) in A/J and C3H/HeJ inbred mice and their offspring. The mean airway response to acetylcholine was greater than sixfold higher in A/J mice as compared with C3H/HeJ mice. Two phenotypes were easily distinguished on the basis of airway responses to acetylcholine in the progeny of A/J and C3H/HeJ mice. These two phenotypes were termed HYPERREACTIVE (after the A/J strain) and HYPOREACTIVE (after the C3H/HeJ strain). The observed frequencies of HYPERREACTIVE and HYPOREACTIVE phenotypes in the (A/J .times. C3H/HeJ) F1; (C3H/HeJ .times. A/J) F1 .times. C3H/HeJ (C3H/HeJ backcross); and the [(A/J .times. C3H/HeJ) F1 .times. (C3H/HeJ .times. A/J)F1] F2 are consistent with a single autosomal recessive gene primarily controlling acetylcholine-mediated airway responses. This single gene difference in airway response is completely inhibited by atropine and therefore mediated entirely by the muscarinic acetylcholine receptor.