Delivery of growth factor-based therapeutics in vascular diseases: Challenges and strategies
Delivery of growth factor-based therapeutics in vascular diseases: Challenges and strategies
复制标题
基于生长因子的血管疾病治疗方法：挑战与策略
DOI：
10.1002/biot.201600243
复制
发表时间：
2017
影响因子：
4.7
通讯作者：
Zhao Ying Zheng
中科院分区：
文献类型：
--
作者：
Xu He Lin;Yu Wen Ze;Lu Cui Tao;Li Xiao Kun;Zhao Ying Zheng
Either cardiovascular or peripheral vascular diseases have become the major cause of morbidity and mortality worldwide. Recently, growth factors therapeutics, whatever administrated in form of exogenous growth factors or their relevant genes have been discovered to be an effective strategy for the prevention and therapy of vascular diseases, because of their promoting angiogenesis. Besides, as an alternative, stem cell‐based therapy has been also developed in view of their paracrine‐mediated effect or ability of differentiation toward angiogenesis‐related cells under assistance of growth factors. Despite of being specific and potent, no matter growth factors or stem cells‐based therapy, their full clinical transformation is limited from bench to bedside. In this review, the potential choices of therapeutic modes based on types of different growth factors or stem cells were firstly summarized for vascular diseases. The confronted various challenges such as lack of non‐invasive delivery method, the physiochemical challenge, the short half‐life time, and poor cell survival, were carefully analyzed for these therapeutic modes. Various strategies to overcome these limitations are put forward from the perspective of drug delivery. The expertised design of a suitable delivery form will undoubtedly provide valuable insight into their clinical application in the regenerative medicine.
