Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via Toll-like receptor 2
Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via Toll-like receptor 2
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DOI：
10.1099/jmm.0.45598-0
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发表时间：
2004-08-01
影响因子：
3
通讯作者：
Poxton, IR
中科院分区：
文献类型：
--
作者：
Erridge, C;Pridmore, A;Poxton, IR
细菌脂多糖（LPS）的识别对于宿主防御革兰氏阴性菌感染至关重要。虽然肠细菌 LPS 通过 Toll 样受体 4 (TLR4) 发出信号，但最近有报道称问号钩端螺旋体、嗜肺军团菌、根瘤菌 Sin-1 和至少一种牙龈卟啉单胞菌菌株的 LPS 能够通过 TLR2 发出信号。使用TLR转染测定和NF-κB敏感启动子区域的测量，结果显示脆弱拟杆菌NCTC-9343、沙眼衣原体LGV-1和铜绿假单胞菌PAC-611的LPS也通过TLR2发出信号，并指出迄今为止发现的所有TLR2信号传导LPS均相对较弱 一些模型中的内毒性和结构特征与通过 TLR4 发出信号的 LPS 不同。
Recognition of bacterial lipopolysaccharide (LPS) is critical in the host defence against Gramnegative infection. While enterobacterial LPS signals via Toll-like receptor 4 (TLR4), it has recently been reported that the LPS of Leptospira interrogans, Legionella pneumophila, Rhizobium species Sin-1 and at least one strain of Porphyromonas gingivalis are capable of signalling via TLR2. Using a TLR transfection assay and measurement of an NF-kappaB-sensitive promoter region, the results show that the LPS of Bacteroides fragilis NCTC-9343, Chlamydia trachomatis LGV-1 and Pseudomonas aeruginosa PAC-611 also signal via TLR2 and it is pointed out that all TLR2-signalling LPS discovered to date demonstrate relatively weak endotoxicity in some models and structural features distinct from those LPS shown to signal via TLR4.