Chemical and Biological Roles of Zinc in a Porous Titanium Dioxide Layer Formed by Micro-Arc Oxidation
Chemical and Biological Roles of Zinc in a Porous Titanium Dioxide Layer Formed by Micro-Arc Oxidation
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DOI：
10.3390/coatings9110705
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发表时间：
2019-10
期刊：
影响因子：
3.4
通讯作者：
Masaya Shimabukuro;Y. Tsutsumi;K. Nozaki;Peng Chen;Risa Yamada;M. Ashida;H. Doi;A. Nagai;T. Ha
中科院分区：
文献类型：
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作者：
Masaya Shimabukuro;Y. Tsutsumi;K. Nozaki;Peng Chen;Risa Yamada;M. Ashida;H. Doi;A. Nagai;T. Ha
研究了含锌电解液微弧氧化处理后多孔二氧化钛中锌的时间瞬态效应。我们分析的目的是了解生理盐水中锌的化学和生物学性质的变化。的锌纳入微弧氧化表面的形态没有改变，和少量的锌离子被释放在早期阶段在盐水中孵育。我们观察到锌的浓度在氧化层中的减少，因为它的释放和化学状态（Zn2+化合物的ZnO）随着时间的推移在盐水中孵育过程中发生变化。此外，在28天的孵育过程后，掺入锌的MAO表面的抗菌性能在后期发展。此外，成骨细胞能够增殖和钙化的标本与锌。生理盐水中与锌有关的变化对成骨细胞无毒性作用。因此，锌在多孔二氧化钛层中的时间瞬态效应有利于实现双重功能，即抗菌性和成骨细胞相容性。我们的研究表明，锌的化学状态的变化，以控制其化学和生物学特性的重要性。
This study investigated the time transient effect of zinc (Zn) in the porous titanium dioxide formed by micro-arc oxidation (MAO) treatment routinely performed for Zn-containing electrolytes. The aim of our analysis was to understand the changes in both the chemical and biological properties of Zn in physiological saline. The morphology of the Zn-incorporated MAO surface did not change, and a small amount of Zn ions were released at early stages of incubation in saline. We observed a decrease in Zn concentration in the oxide layer because its release and chemical state (Zn2+ compound to ZnO) changed over time during incubation in saline. In addition, the antibacterial property of the Zn-incorporated MAO surface developed at late periods after the incubation process over a course of 28 days. Furthermore, osteogenic cells were able to proliferate and were calcified on the specimens with Zn. The changes related to Zn in saline had non-toxic effects on the osteogenic cells. In conclusion, the time transient effect of Zn in a porous titanium dioxide layer was beneficial to realize dual functions, namely the antibacterial property and osteogenic cell compatibility. Our study suggests the importance of the chemical state changes of Zn to control its chemical and biological properties.