Increased accuracy of ligand sensing by receptor diffusion on cell surface.
Increased accuracy of ligand sensing by receptor diffusion on cell surface.
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DOI：
10.1103/physreve.82.041902
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
G. Aquino;R. G. Endres
中科院分区：
文献类型：
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作者：
G. Aquino;R. G. Endres
细胞感觉到外部配体浓度的物理极限对应于完美的吸收体，在那里所有的配体颗粒都被吸收，并且不会发生相同的配体颗粒的过度计数。在这里，我们分析了受体在细胞膜上的侧向扩散如何影响配体浓度传感的准确性。具体地说，我们将我们的建模与神经突触中的神经传递联系起来，在那里谷氨酸受体的扩散已经被认为可以刷新突触连接。我们发现，受体扩散确实提高了对谷氨酸α-Amino-3-hydroxy-5-Methyl-4-isoxazolePropionic酸(AMPA)和N-甲基-D-天冬氨酸(N-甲基-D-天冬氨酸)受体的感知准确性，尽管N-甲基-D-天冬氨酸受体总体上噪音要大得多。我们认为，这两种受体在感觉准确性上的差异可能与它们在神经传递中的不同作用有关。具体地说，对谷氨酸的高精度感知是AMPA受体启动膜去极化的关键，而NMDA受体被认为在第二阶段作为符合检测器工作，参与长期增强和记忆。
The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here, we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration. Specifically, we connect our modeling to neurotransmission in neural synapses where the diffusion of glutamate receptors is already known to refresh synaptic connections. We find that receptor diffusion indeed increases the accuracy of sensing for both the glutamate α-Amino-3-hydroxy-5-Methyl-4-isoxazolePropionic Acid (AMPA) and N-Methyl-D-aspartic Acid (NMDA) receptor, although the NMDA receptor is overall much noisier. We propose that the difference in accuracy of sensing of the two receptors can be linked to their different roles in neurotransmission. Specifically, the high accuracy in sensing glutamate is essential for the AMPA receptor to start membrane depolarization, while the NMDA receptor is believed to work in a second stage as a coincidence detector, involved in long-term potentiation and memory.